amos b smith n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Amos B. Smith PowerPoint Presentation
Download Presentation
Amos B. Smith

Loading in 2 Seconds...

play fullscreen
1 / 29

Amos B. Smith - PowerPoint PPT Presentation


  • 219 Views
  • Uploaded on

Amos B. Smith. Mounuo Cheng 20100911. Prof. Amos B. Smith. Amos B. Smith, III (born August 26, 1944) 1966 Bucknell University's first combined four-year B.S.-M.S. degree in Chemistry. 1972 Ph.D. degree at Rockefeller University 1973 join University of Pennsylvania

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Amos B. Smith' - gene


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
amos b smith

Amos B. Smith

Mounuo Cheng

20100911

prof amos b smith
Prof. Amos B. Smith

Amos B. Smith, III (born August 26, 1944)

1966 Bucknell University's first combined four-year B.S.-M.S. degree in Chemistry.

1972 Ph.D. degree at Rockefeller University

1973 join University of Pennsylvania

1998 he became the first Editor-in-Chief of the new American Chemical Society journal, Organic Letters.

Rhodes-Thompson Professor of Chemistry

University of Pennsylvania,

slide3
Smith's research interests encompass three diverse areas: natural product synthesis, bioorganic chemistry and materials science.
  • To date more than 90 architecturally complex natural products have been prepared in his Laboratory.
  • Smith, in collaboration with Ralph Hirschmann, has achieved the design and synthesis of non-peptide peptidomimetics of neuropeptideic hormone/transmitters and protease enzyme inhibitors and,
  • also with Stephen Benkovic (Penn State), haptens for the production of catalytic antibodies capable of peptide bond formation.
  • At Monell, in collaboration with Peter Jurs (Penn State), he pioneered the use of computerized pattern recognition techniques for the analysis of primate chemical communication.
total synthesis of kendomycin petasis ferrier rearrangement ring closing olefin metathesis strategy
Total Synthesis of (-)-Kendomycin Petasis-Ferrier Rearrangement/Ring-Closing OlefinMetathesis Strategy

J. AM. CHEM. SOC. 2006, 128, 5292-5299

total syntheses of lyconadin a and lyconadin b
Total Syntheses of (+)-Lyconadin A and (-)-Lyconadin B

J. AM. CHEM. SOC. 2007, 129, 4148-4149

total synthesis of okilactomycin
Total Synthesis of (-)-Okilactomycin

J. AM. CHEM. SOC. 2007, 129, 14872-14874

total syntheses of the assigned structures of lituarines b and c
Total Syntheses of the Assigned Structures of Lituarines B and C

J. AM. CHEM. SOC. 2008, 130, 422-423

total synthesis of sorangicin a
Total Synthesis of (+)-Sorangicin A

J. AM. CHEM. SOC. 2009, 131, 12109–12111

penitrem d
(-)-Penitrem D

a highly substituted indole core,

a cyclobutane moiety,

an eight-membered cyclic ether

nine fused rings,

eleven stereogenetic carbons,

and two allylic hydroxyl groups.

The indole-diterpene tremogens comprise an important family

of environmental toxins, produced by ergot fungi that grow on a

variety of grasses endemic to South Africa, New Zealand and

the United States.

slide10
当 AB Smith 完成了 Penitrem D (the longest linear sequence 43sateps) 的全合成之后, Gilbert Stork 在   Chemical and Engineering News 上评论道"......If each one of 12 master synthesizers concocts what he or she believes to be the most efficient or elegant route to a target, the result will be 12 different approaches. Smith has certainly reached a place within that group of more or less a dozen organic chemists in the world who are capable of constructing molecules as complex as penitrem D."
slide11

Retrosynthesis analysis

Jacs. 2000, 122, 11254-11255

Jacs,2003, 125, 8228-8237

modified madelung indole formation
Modified Madelung indole formation

Moffat oxidation reaction

retrosynthesis analysis
Retrosynthesis analysis

Jacs. 2000, 122, 11254-11255

Jacs,2003, 125, 8228-8237