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Amos B. Smith

Amos B. Smith

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Amos B. Smith

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  1. Amos B. Smith Mounuo Cheng 20100911

  2. Prof. Amos B. Smith Amos B. Smith, III (born August 26, 1944) 1966 Bucknell University's first combined four-year B.S.-M.S. degree in Chemistry. 1972 Ph.D. degree at Rockefeller University 1973 join University of Pennsylvania 1998 he became the first Editor-in-Chief of the new American Chemical Society journal, Organic Letters. Rhodes-Thompson Professor of Chemistry University of Pennsylvania,

  3. Smith's research interests encompass three diverse areas: natural product synthesis, bioorganic chemistry and materials science. • To date more than 90 architecturally complex natural products have been prepared in his Laboratory. • Smith, in collaboration with Ralph Hirschmann, has achieved the design and synthesis of non-peptide peptidomimetics of neuropeptideic hormone/transmitters and protease enzyme inhibitors and, • also with Stephen Benkovic (Penn State), haptens for the production of catalytic antibodies capable of peptide bond formation. • At Monell, in collaboration with Peter Jurs (Penn State), he pioneered the use of computerized pattern recognition techniques for the analysis of primate chemical communication.

  4. Total Synthesis of (-)-Kendomycin Petasis-Ferrier Rearrangement/Ring-Closing OlefinMetathesis Strategy J. AM. CHEM. SOC. 2006, 128, 5292-5299

  5. Total Syntheses of (+)-Lyconadin A and (-)-Lyconadin B J. AM. CHEM. SOC. 2007, 129, 4148-4149

  6. Total Synthesis of (-)-Okilactomycin J. AM. CHEM. SOC. 2007, 129, 14872-14874

  7. Total Syntheses of the Assigned Structures of Lituarines B and C J. AM. CHEM. SOC. 2008, 130, 422-423

  8. Total Synthesis of (+)-Sorangicin A J. AM. CHEM. SOC. 2009, 131, 12109–12111

  9. (-)-Penitrem D a highly substituted indole core, a cyclobutane moiety, an eight-membered cyclic ether nine fused rings, eleven stereogenetic carbons, and two allylic hydroxyl groups. The indole-diterpene tremogens comprise an important family of environmental toxins, produced by ergot fungi that grow on a variety of grasses endemic to South Africa, New Zealand and the United States.

  10. 当 AB Smith 完成了 Penitrem D (the longest linear sequence 43sateps) 的全合成之后, Gilbert Stork 在   Chemical and Engineering News 上评论道"......If each one of 12 master synthesizers concocts what he or she believes to be the most efficient or elegant route to a target, the result will be 12 different approaches. Smith has certainly reached a place within that group of more or less a dozen organic chemists in the world who are capable of constructing molecules as complex as penitrem D."

  11. Retrosynthesis analysis Jacs. 2000, 122, 11254-11255 Jacs,2003, 125, 8228-8237

  12. Amberlyst-15 离子树脂,烷基化催化剂

  13. 模版反应

  14. Modified Madelung indole formation Moffat oxidation reaction

  15. MTM=CH2SCH3

  16. Retrosynthesis analysis Jacs. 2000, 122, 11254-11255 Jacs,2003, 125, 8228-8237

  17. thanks for your attention!!