the avon longitudinal study of parents and children alspac children of the 90s n.
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The Avon Longitudinal Study of Parents and Children (ALSPAC): Children of the 90s. Study Description. KEY FEATURES Population based Geographically defined Recruited during pregnancy Detailed follow-up, including hands-on measures Linked biological samples.

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the avon longitudinal study of parents and children alspac children of the 90s

The Avon Longitudinal Study of Parents and Children (ALSPAC):Children of the 90s

Study Description

slide2
KEY FEATURES

Population based

Geographically defined

Recruited during pregnancy

Detailed follow-up, including hands-on measures

Linked biological samples

slide3
All pregnant women resident in Avon
  • Expected date of delivery 1.4.91-31.12.92
  • Recruited through antenatal clinics
slide4
RECRUITMENT

14,541 pregnancies (14,472 outcome known)

14,676 fetuses  14,062 live births

13,988 children alive at 1 year

542 children added at age 7 years

10% sample (Children in Focus) attended clinics 4 months - 5 years (n = 1,432)

slide6

100%

90%

80%

70%

60%

50%

40%

30%

20%

10%

0%

-10

0

10

20

30

40

50

60

70

80

90

Cohort retention

Age of child (months)

slide7
DATA - QUESTIONNAIRES

Questionnaires to:

Mother about herself

Mother’s partner

Mother about Child

4 questionnaires to mother in pregnancy

6 months after birth and annual thereafter

slide8
DATA – HANDS-ON

Children in Focus – 4m-5y

Whole cohort – Annual clinics 7-15 years

Current status – 17 year clinic running

Multifaceted study of health, development and disease of children

slide9
FOCUS AT 7
  • Eight sessions of 20 min
  • Total clinic 2h 40min
  • Measures based on scientific priority (& cost)
  • 17+ clinic c.£3m
slide10
BIOLOGICAL SAMPLES

DNA maternal, cord & 7y venous blood; transformed cell lines in progress

DNA 10,000 mothers and children

C. 1,000 partners

Aim for 6,000 trios at end of current programme

Blood (most <5 y gone); later fasting blood for metabolic studies

Placentae, hair, teeth, urine (cotinine @ 8y and 15y)

slide11
ENVIRONMENT

Mostly questionnaire based; but dating back to pregnancy

Some small validation studies (NO2, salivary cortisols, etc.)

Modelling pollution exposures

Strengths: Diet (FFQ & diaries); Smoking; Pollution; Activity and body mass (accelerometers & DXA scans @ 9, 11, 13 years)

slide12
ASTHMA & ALLERGY

Questionnaire data on wheezing, asthma, eczema & hay fever from 6m-17y

Skin exam for eczema @ 5y (CiF) & 7y

SPTs and total serum IgE @ 7y

Spiro & BR methacholine @ 8y

Spiro & FeNO & BD reversibility @ 15y

slide13
GWAS – CURRENT STATUS

1,400 samples Illumina 317k (WTCCC)

1,250 asthma case:control Illumina 610k (GABRIEL II)

Expect asthma candidates on c.7,000 (GABRIEL Phase III)

Applying for genome wide typing of whole cohort (?????)