Cholinoceptor blocking drugs:. M1, M2, M3, M4, M5,. Neuromuscular junction blockers (N M ). Ganglion blockers (N N ). Anti Muscarinic Anti Nicotinic. By: Dr. Sumbul. Basic Pharmacology of Muscarinic Receptor blocking drugs:
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M1, M2, M3, M4, M5,
Anti Muscarinic Anti Nicotinic
By: Dr. Sumbul
central nervous system
I. Central nervous system
Linger lasting sedation by action on parasympathetic medullary centres.
Scopolamine has marked central effects include drowsiness and amnesia in sensitive individuals in recommended doses.
Used in Parkinson’s disease as adjunctive therapy with levodopa.
b. BLOOD VESSELS:
Almost all vessels contain endothelial muscarinic receptors that mediates vasodilation.
Diarrhea due to over dosage of parasympathomimetic drug is readily stopped. And even
OXYBUTYNIN is used for the relief of bladder spasm after the urologic surgery
A traditional mnemonic for atropine toxicity is “Dry as a bone, red as a beet,
mad as a hatter”.
GANGLION BLOCKING DRUGS.
These agents block the action of Ach and similar agonist at the nicotinic receptors of both parasympathetic and sympathetic autonomic ganglia.
Hypotension is especially marked in the upright position (orthostatic or postural
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