CHAPTER 7: PSYCHOMOTOR STIMULANTS. Brought to you by: Stephanie Andrus, Kimberly Bernosky and Steve Marshall. General Effects of Psychomotor Stimulants:. Increase in behavioral and motor activity Increase in alertness and disruption of sleep
Brought to you by:
and Steve Marshall
Peak reached in 30-60 minutes
Onset of effect in 8-10 seconds.
6-32% reaching plasma.
Peak plasma levels reached at 5 minutes, persisting for 30 minutes.
Onset of effect in 30-60 sec
CNS effects are caused by release of NE and DA from presynaptic storage sites in the nerve terminals, increasing the amounts available at the postsynaptic receptor (see attached Figure 7.2, page 186 in the text)