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This study explores the synergistic effects of DCB and VPA combined with TRAIL in cancer cells, investigating apoptosis pathways and b-actin expression. Results show promising potential for enhanced cancer therapy.
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A - - + + - - + + - - - - + + + + - + - + - + - + DCB VPA LC3-I TRAIL LC3-II b-actin B - CQ, 25 μM 8.5 0.9 1.4 0.4 - 14.1 76.5 4.8 93.4 7.1 0.9 2.5 0.2 TRAIL 15.6 76.4 7.4 89.9 Propidium iodide 28.4 2.2 10.1 0.3 DCB+VPA 38.4 31.0 21.8 67.8 40.2 2.2 24.1 0.9 DCB+VPA +TRAIL 37.5 20.1 24.5 50.5 Annexin V Supplementary Figure 4