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THE KREB’S CYCLE What Goes Around Comes Around

THE KREB’S CYCLE What Goes Around Comes Around. The Krebs Cycle What Goes Around Comes Around. Part 1: Preparation of Pyruvate. Mitochondria Outer Membrane. Cytosol. Mitochondria. NAD+. NADH. (2C) Acetic Acid. H. CO 2. Coenzyme A. Acetyl – Coenzyme A. Pyruvate (3C).

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THE KREB’S CYCLE What Goes Around Comes Around

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  1. THE KREB’S CYCLE What Goes Around Comes Around

  2. The Krebs Cycle What Goes Around Comes Around Part 1: Preparation of Pyruvate Mitochondria Outer Membrane Cytosol Mitochondria NAD+ NADH (2C) Acetic Acid H CO2 Coenzyme A Acetyl – Coenzyme A Pyruvate (3C) Transport Protein

  3. Acetyl CoA Part 2: Kreb’s Cycle (2C) CoEnzyme A NADH H2O NAD+ Oxaloacetate (4C) Malate (4C) Citrate (6C) Isocitrate (6C) CO2 THE KREB’S CYCLE NAD+ H2O NADH CoEnzyme A Fumarate (4C) CoEnzyme A a-Ketoglutarate (5C) FADH FAD+ NAD+ CO2 TOTALS Succinate (4C) GTP GDP NADH ATP = 1 X 2 = 2 Succinyl- CoA (4C) NADH = 4 X 2 = 8 ADP FADH = 1 X 2 = 2 ATP CO2 = 3 X 2 = 6 Kreb’s Cycle Song

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  5. The Krebs Cycle melody and lyrics by Lynda Jones; adapted by Do Peterson and Greg Crowthe Greg: geek vocals, keyboard Lori: lead vocals Kirk L. Van Scoyoc: banjo Do: bass, hyper-dramatic vocals, keyboard, acoustic and electric guitar, drum Acetyl CoA combines with oxaloacetic acid To create a citric acid. That's how it begins. Then a water removed and added makes it isocitric acid, Which, in turn, oxidized and loses CO2. Then alpha-ketoglutaric is oxidized again, Losing carbon dioxide with an NADH spin. Then through a phosphorylation Succinyl CoA congeals a GDP to GTP to toss back CoASH. CHORUS:Acetyl CoA, citric acid, iso-,Alpha-ketoglutaric, succinyl CoA,Succeeded by succinic, fumaric and malic,Then oxaloacetic starts the cycle again. CHORUS Soon we see succinic acid forming a fumaric acid As it forms an FADH2 along the way. Water washed upon fumaric makes it into acid malic. Now there's only one step left, so let's be on our way. With one more oxidation, resisting degradation, A final NADH is made and brings us to the end. Oxaloacetic acid, first and last, a simple acid Then accepts an acetyl CoA and starts again.

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