synaptic transmission. Basic Neuroscience NBL 120 (2007). how is the signal transferred?. electrical currents in the presynaptic process induce currents in the postsynaptic process not very efficient………. high. low. how do synapses work?.
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Basic Neuroscience NBL 120 (2007)
“I vividly remember visiting him [Eccles] in his pleasant house with its fine tennis court and beautiful view over Sydney harbor.” (Katz, 1985)
pharmacologists versus physiologists
10,000 / m2
non-selective cation channel
smallest evoked EPP = spontaneous mEPP
“It has been suggested that the end-plate potential (epp) at a single nerve-muscle junction is built up statistically of small all-or-none units [quanta or discrete packets of transmitter] which are identical in size with the spontaneous ‘miniature epp’s’” (Del Castillo & Katz, 1954)
Fatt and Katz (1952)
normal EPP ≈ 200 quanta or vesicles (quantal content)
Llinas et al (1995)
Katz and Miledi (1973)
how do the multiple inputs combine to determine the output firing pattern of the neuron?
integration and other mechanisms
just how much glutamate is around?