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Chapter 11. Chromosomal Basis of Inheritance. Mendel’s inheritance with independent assortment. Mendel had factors, we now know these factors were specific genes at specific loci, (locations) on specific chromosomes. This is the chromosome theory of inheritance.

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chapter 11

Chapter 11

Chromosomal Basis of Inheritance

slide4

Mendel had factors, we now know these factors were specific genes at specific loci, (locations) on specific chromosomes. This is the chromosome theory of inheritance.

morgan s experiments with fruit flies
Morgan’s experiments with Fruit Flies

A.Morgan usedfruit fliesto trace a gene to a specific chromosome

slide6

1. Drosophila Melangaster – wildtype phenotype = most common and mutant phenotypes = caused by mutations of the wildtype gene.

  • 2. Sex-linked- using the gene for white eyes Morgan found that if a female had the trait and mated to a male with wildtype, only her sons would be white-eyed.
sex linkage
Sex Linkage

This meant the gene must be on the X and not the Y.

A daughter would receive the wildtype X from the father which would override the faulty X from mom.

linked genes genes close together on the same chromosome
Linked genes – genes close together on the same chromosome
  • Morgan found that flies have linked genes for body color and wing size.
  • Gray and normal wings were wildtype, black and vestigal wings were mutant types.
  • Gray flies with vestigal wings and black flies with normal wings are much harder to breed than the ones in b.
slide9

Independent assortment

  • Genes which are not linked sort independent of one another.When they come together in a zygote it is called recombination.
      • A frequency of 50% or more recombination means the genes are not linked
      • b. Linked genes do not sort independently, they travel together, making recombination percentages low.
slide10
If the genes are far apart they behave as if they were on different chromosomes
  • This slide shows recombination during meiosis.
sex chromosomes
Sex chromosomes

A. In humans XX is female and XY is male

  • The SRY gene has been shown to trigger the development into a male fetus at about 2 months old.
  • SRY probably regulates other genes

3. Some XX male and XY females exist with mutated SRY genes

sex linked
Sex-linked
  • Genes on the X chromosome will only be present in one copy in males, as they only have one X and the Y does not contain the same genes.
slide14

Males are said to be hemizygous for these traits

      • Colorblindness is an example of a non- lethal sex-linked trait- females can acquire it from their father (colorblind) and mother (carrier).
      • Duchene muscular dystrophy – weakening of the muscles,1/3500 males- usually die by 20s
      • Hemophilia- absence of certain clotting factors.
slide15
In females one X becomes inactivated and condenses into a Barr body, which one is inactive is random, and will be different in different cells.Ex.tortoise shell cats
errors
Errors

A. Nondisjunction- when meiosis is not accurate and some cells are missing a chromosome (anueploidy) and one has too many chromosomes(polyploidy)

slide20

Other nondisjunctions

  • Metafemale - XXX
  • 2. Turner – X0
slide21

Other errors

      • A. Deletions – Chromosome fragment is lost
      • 1. Cri-du-chat- chromosome 5
      • B.Duplication – chromosome fragment attached to homologue
      • C.Inversion – reverse orientation of fragment on chromosome
      • D.Translocation – fragment on a nonhomologue
      • 1. Implications of cancer - CML
imprinting
Imprinting
  • Genomic imprinting – One active copy either maternal or paternal.
  • Fragile X – caused in part by maternal imprinting.
slide23

Extranuclear genes

      • A. Small circular DNA in mitochondria and chloroplasts
  • B. Maternal inheritance is the rule