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Notes: Sliding Filament Theory. [Muscle Contraction Physiology]. (1) Muscle Contraction. Sliding Filaments = Muscle Contraction The Basic Steps: 1- Message sent 2- Neurotransmitter 3- Depolarization 4- Calcium + Troponin = Actin Exposed 5- Actin + Myosin (Contraction).

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notes sliding filament theory

Notes: Sliding Filament Theory

[Muscle Contraction Physiology]

1 muscle contraction
(1) Muscle Contraction
  • Sliding Filaments = Muscle Contraction
  • The Basic Steps:

1- Message sent

2- Neurotransmitter

3- Depolarization

4- Calcium + Troponin = Actin Exposed

5- Actin + Myosin (Contraction)

2 neuron muscle muscle fiber
(2) Neuron  Muscle (Muscle Fiber)
  • Cause:
    • Conscious decision to move
    • Homeostatic response
  • Nervous System  Effector
    • Neurotransmitter released (ACh, acetylcholine)
    • ACh binds to sarcolemma of muscle fiber
    • ACh initiates opening of sodium-potassium channels
3 depolarization
(3) Depolarization
  • Cause:
    • Binding of ACh to sodium-potassium channels
    • Opening of channels + Movement of Na-K+ across sarcolemma
  • Movement of Charges:
    • More Na+ moves in, Than K+ moves out
    • Imbalance of charges  electrical current (action potential)
4 sarcoplasmic reticulum calcium
(4) Sarcoplasmic Reticulum  Calcium
  • Cause: Depolarization
  • Action Potential releases Calcium:
    • Ca+ released from membrane of sarcoplasmic reticulum to sarcomere
    • Ca+ binds with troponin:
      • Troponin-Tropomyosion conformation changes
      • Troponin & Tropomyosin no longer cover Actin
      • Actin is exposed
5 myosin actin
(5) Myosin  Actin
  • Cause:
    • Troponin & Tropomyosin unveils Actin
    • Actin exposed
  • Myosin releases Inorganic Phosphate + ADP
    • Pi + ADP = ATP
    • Myosin changes conformation
    • Myosin binds to Actin
    • Myosin and Actin slide towards each other
    • WE HAVE A CONTRACTION! WOO WOO!
6 relaxation
(6) Relaxation
  • ATP binds back with myosin…
    • Myosin detaches and moves away from Actin
    • Troponin & Tropomyosin cover up Actin
    • Ca+ moves back into Sarcoplasmic Reticulum
    • Repolarization  Sarcolemma stable again
7 why is it called the sliding filament theory
(7) Why is it called the Sliding Filament Theory?
  • Movement of myofilaments causes contraction
  • Myosin grabs actin & SLIDES them towards the center
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(1-2) Depolarization of Sarcolemma & Generation of Action Potential

(3) Calcium Ions released from Sarcoplasmic Reticulum

(10) Everything moves back & contraction done!

(4-6) Calcium binds to troponin, tropomyosin moves, actin exposed

(9) Calcium removed by active transport

(7-8) Myosin attaches to actin, Myosin moves actin, ATP released