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Measles

Measles. Franklin Jones. Measles. Franklin Jones 4/3/2012. Early History of Measles.

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Measles

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  1. Measles Franklin Jones Measles Franklin Jones 4/3/2012

  2. Early History of Measles • First reports of measles date back to 700 AD, but the first scientific description was featured in Muhammad ibn Zakariya ar-Razi’s “Kitab fi al-jadari wa-al-hasbah” (The Book of Smallpox and Measles) c. 900 AD. • This account was also first distinction from smallpox and chickenpox

  3. Not just an artifcact of our grandparent’s generation

  4. Remains a threat to children of the 3rd world

  5. Symptoms a b c 3 C’s

  6. Only six structural proteins

  7. From Me(asles) to You a

  8. The virus enters a host cell

  9. From here on out…

  10. Pick an organ, any organ

  11. Clinical symptoms are present after incubation period c d

  12. Not done yet Viral shedding

  13. The virus must return to the epithelium

  14. Clinical diagnosis is most common 4 Day Fever Observation of one of the 3 C’s (cough, coryza, conjuctivits)

  15. The body fights back

  16. Treatment is not strictly palliative • Can not kill virus, but can alleviate symptoms • IV fluids • Fever medication • Antibiotics for secondary infetions (PSSE) • Vitamin A supplement • Subacute sclerosing panencephalitis (PSSE)

  17. Antibodies are able to ward off infection • Live attennuated • Edmonston B or Schwartz stains90% seroconversion -Often incorporated with rubella and/or mumps vaccine

  18. Bright Future • The Measles Initiative- collaborative effort of WHO, UNICEF, ICRC, CDC, and UN + various private and public partners • Mortality decreased by 74% between 2000 and 2007, from an estimated 750,000 to 197,000…this achieved the UN’s goal to reduce measles deaths by 90% by 2010, three years early

  19. Side effects of vaccine?

  20. Additional Links • http://www.youtube.com/watch?v=iPQZyt_EoGw- Amnest International Video • http://www.youtube.com/watch?v=v80kA_dt6EE- Histopathology of Measles-Pneumonia • http://digital.films.com.libproxy.lib.unc.edu/PortalViewVideo.aspx?xtid=35512 - BBC

  21. Picture References • Slide 1http://www.inquisitr.com/164771/measles-outbreak-spreading-across-europe/ • Slide 2- http://www.payvand.com/news/07/aug/Persian-Scientists_files/image012.jpg • Slide 3 - Bryce, Jennifer. "WHO Estimates of the Causes of Death in Children." The Lancet 365(2005): 1147-1152. Web. 28 Mar. 2012. <http://ih.stanford.edu/rosenfield/resources/WHO%20Estimates%20of%20COD%20in%20Kids.pdf>. • Slide 4 – Ibid • Slide 5a- http://newspaper.li/measles/ • Slide 5b- http://www.nlm.nih.gov/medlineplus/ency/images/ency/fullsize/2558.jpg • Slide 5c- http://www.nlm.nih.gov/medlineplus/ency/images/ency/fullsize/19322.jpg • Slide 6- Moss, William. "Global Measles Elimination." Nature 4(2006): 900-908. Web. 28 Mar. 2012. <http://www.nature.com/nrmicro/journal/v4/n12/full/nrmicro1550.html>. • Slide 7a- http://upload.wikimedia.org/wikipedia/commons/thumb/7/77/Sneeze.JPG/300px-Sneeze.JPG • Slide 7b- Moss, William. "Global Measles Elimination." Nature 4(2006): 900-908. Web. 28 Mar. 2012. <http://www.nature.com/nrmicro/journal/v4/n12/full/nrmicro1550.html>. • Slide 8 – Yanagi, Yusuke. "Measles Virus: Cellular Receptors, Tropism and Pathogenesis." Journal of General Virology 87(2006): 2767-2779. Web. 27 Mar. 2012. <http://www.jstage.jst.go.jp/article/jsv/56/1/56_27/_article>. • Slide 9 - Moss, William. "Global Measles Elimination." Nature 4(2006): 900-908. Web. 28 Mar. 2012. <http://www.nature.com/nrmicro/journal/v4/n12/full/nrmicro1550.html>.

  22. Cont. • Slide 10 – Ibid • Slide 11b- Ibid • Slide 11c- http://www.nlm.nih.gov/medlineplus/ency/images/ency/fullsize/2558.jpg • Slide 11d- - http://newspaper.li/measles/ • Slide 12 – Moss, William. "Global Measles Elimination." Nature 4(2006): 900-908. Web. 28 Mar. 2012. <http://www.nature.com/nrmicro/journal/v4/n12/full/nrmicro1550.html>. • Slide 13- Racaniello, Vincent. "An Exit Strategy for Measles Virus." Science 334.6063 (2011): 1650-1651. Web. 27 Mar. 2012. <http://www.sciencemag.org/content/334/6063/1650.full>. • Slide 14 – http://www.google.com/imgres?q=doctor+treating+child&um=1&hl=en&sa=N&biw=687&bih=679&tbm=isch&tbnid=ThZzyS0v7XT8hM:&imgrefurl=http://www.doctorswithoutborders.org/news/article.cfm%3Fid%3D3203&docid=5fEpKNCMXdlAjM&imgurl=http://www.doctorswithoutborders.org/images/news/2008/Zimbabwe-34932.jpg&w=550&h=413&ei=vu96T_20FIzO9ATT_dmaBQ&zoom=1&iact=rc&dur=299&sig=104733455050295071052&page=2&tbnh=151&tbnw=231&start=10&ndsp=13&ved=1t:429,r:8,s:10&tx=140&ty=98 • Slide 15- Moss, William. "Global Measles Elimination." Nature 4(2006): 900-908. Web. 28 Mar. 2012. <http://www.nature.com/nrmicro/journal/v4/n12/full/nrmicro1550.html>.

  23. Cont. • Slide 17 – http://www.google.com/imgres?q=MMR&um=1&hl=en&sa=N&biw=687&bih=679&tbm=isch&tbnid=dIFhsmQJYnESSM:&imgrefurl=http://www.qcc.cuny.edu/healthServices/mmrClinics.html&docid=W3v5BNv_CSpxqM&imgurl=http://www.qcc.cuny.edu/healthServices/HSImages/mmr.jpg&w=250&h=252&ei=BfB6T6WzCYGm8gT1svz2BA&zoom=1&iact=rc&dur=385&sig=104733455050295071052&page=1&tbnh=130&tbnw=129&start=0&ndsp=12&ved=1t:429,r:1,s:0&tx=52&ty=54 • Slide 19 - http://www.cmaj.ca/content/182/4/E199/F1.large.jpg

  24. Other Sources • Moss, William. "Global Measles Elimination." Nature 4(2006): 900-908. Web. 28 Mar. 2012. <http://www.nature.com/nrmicro/journal/v4/n12/full/nrmicro1550.html> • Racaniello, Vincent. "An Exit Strategy for Measles Virus." Science 334.6063 (2011): 1650-1651. Web. 27 Mar. 2012. http://www.sciencemag.org/content/334/6063/1650.full. • Yanagi, Yusuke. "Measles Virus: Cellular Receptors, Tropism and Pathogenesis." Journal of General Virology 87(2006): 2767-2779. Web. 27 Mar. 2012. <http://www.jstage.jst.go.jp/article/jsv/56/1/56_27/_article>. • Bryce, Jennifer. "WHO Estimates of the Causes of Death in Children." The Lancet 365(2005): 1147-1152. Web. 28 Mar. 2012. <http://ih.stanford.edu/rosenfield/resources/WHO%20Estimates%20of%20COD%20in%20Kids.pdf>.

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