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CRISP AMI . Objective To determine if routine intra-aortic balloon pump (IABP) placement prior to reperfusion in patients with anterior STEMI without shock reduces infarct size Study Design Randomized, open-label, multicenter, controlled trial

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crisp ami
CRISP AMI

Objective

  • To determine if routine intra-aortic balloon pump (IABP) placement prior to reperfusion in patients with anterior STEMI without shock reduces infarct size

Study Design

  • Randomized, open-label, multicenter, controlled trial
  • 337 patients randomized to either IABP prior to PCI (n=161) or standard PCI with “bailout” IABP (n=176)

Primary Endpoint

  • Infarct size as measured by cardiac MRI

Secondary Endpoints

  • All-cause death at 6 months
  • Vascular complications and major bleeding at 30 days
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CRISP AMI

Results

  • Mean infarct size was not statistically significantly different between the patients in the IABP plus PCI group and those in the standard PCI group (42.1% vs 37.5%, respectively; p=0.06)

Primary Endpoint

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CRISP AMI

Conclusions

  • Compared with PCI alone, IABP plus primary PCI did not result in reduced infarct size among patients with acute anterior STEMI without shock
  • All-cause mortality at 6 months did not differ significantly between the two groups