1 / 11

BDNF Upregulation in Monkey Cortex for Visual Pair-Association Memory

This study by Tokuyama et al. delves into the upregulation of BDNF in the inferior temporal cortex during the formation of visual pair-association memory in monkeys. The research reveals that BDNF expression increases in specific areas of the cortex crucial for long-term memory, shedding light on neural circuit reorganization. Techniques included mRNA expression comparison within animals and visual memory task implementation. In a related study by Kevin D. Board et al., the transition from olfactory to visual sheep recognition is examined, investigating BDNF and trk-B mRNA expression shortly after partum in olfactory and visual systems.

brett-potter
Download Presentation

BDNF Upregulation in Monkey Cortex for Visual Pair-Association Memory

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Memory Circuits of the Cortex and Limbic Systems

  2. BDNF upregulation during declarative memory formation in monkey inferior temporal cortex Tokuyama et al

  3. The Basics • The inferior temporal cortex stores visual pair association memory. • Tested the hypothesis that BDNF would be upregulated in IT cortex during formation of visual pair-association memory. • Found BDNF was upregulated selectively in area 36 of IT cortex during PA learning, but not in areas involved in earlier stages of visual processing. • Suggests that BDNF contributes to reorganization of neural circuits for visual long-term memory formation in the primate

  4. Methods:Three experimental strategies • Intra-animal comparison of mRNA expression • A visual memory task as the control vs. a no-task condition • Trained the monkeys to first learn a “rule” or “strategy” component of the tasks with training stimulus sets; a test stimulus was then introduced for new learning of declarative components.

  5. Increased BDNF and trk-B mRNA expression in cortical and limbic regions following formation of a social recognition memory • Kevin D. Board et al

  6. The Basics • Sheep recognition: olfactory evolving to visual • Investigate BDNF & trk-B mRNA expression 4.5 hours post partum in olfactory/visual systems

More Related