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Emotional Memory ( The Prefrontal Cortex) & Phineas Gage . B9902052 陳 黎 B9902068 曾資斌. A Gruesome but True Story. Phineas P. Gage (1823 –1860) construction foreman left frontal lobe destroyed effects  ? "no longer Gage". 左前額葉與生理機能無關. 生理機能正常. 左前額葉皮質嚴重損壞.

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a gruesome but true story
A Gruesome but True Story
  • Phineas P. Gage (1823 –1860)
  • construction foreman
  • left frontal lobe destroyed
  • effects  ?
  • "no longer Gage".
slide3

左前額葉與生理機能無關

生理機能正常

左前額葉皮質嚴重損壞

左前額葉與情緒表現相關

情緒表現異常

How?

The Limbic System

  • Before&After
take a closer look
Take a Closer Look……
  • Before
  • After
  • Why?? Prefrontal cortex damaged

Emotionally

detached

impatient

erratic

prefrontal cortex pfc
Prefrontal cortex(PFC)
  • Frontal lobe
  • granular
  • electrical stimulation

Motor cortex

Premotor area

Prefrontal cortex

  • evoke movements
function
Function
  • Importance?
  • CEO of the brain
  • Jiminy cricket

“It is the tiny voice help you decide what is right and wrong.”

when pfc goes wrong
When PFC goes wrong…
  • 運作過度……
  • 活動低落……

(lack of dopamine)

what happened to gage
What happened to Gage?
  • Destroyed
  • Not destroyed
pfc adhd
PFC & ADHD
  • 意力不足過動障礙症(過動症)
  • Attention Deficit Hyperactivity Disorder
  • Why?
  • Dopamine
  • dopadecarboxylase

多巴脫羧酵素

lobotomy
Lobotomy 前額葉切離手術
  • Egas Moniz, 1935
  • Schizophrenia, clinical depression
  • Connections to PFC
reference
Reference
  • PHINEASGAGE:AGruesome but True Story About Brain Science,

by John Fleischman, 2002

  • Making A Good Brain Great, by Daniel G. Amen, 2007
  • 認識你的頭腦, 洪祖培教授、邱浩彰醫師著
  • http://en.wikipedia.org/wiki/Prefrontal_cortex
  • http://en.wikipedia.org/wiki/Lobotomy
  • http://www.dls.ym.edu.tw/neuroscience/adhd_c.html
  • http://sanitaryplaza.blogspot.com/2007/07/lobotomy.html