Rheumatoid Arthritis “An Autoimmune Mystery”. Cynthia Anderson. Dedicated to the memory of my late brother in law, Sherman F. Grace 1945-1991. He never let RA stop him from having a full productive life. What is Rheumatoid Arthritis?.
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He never let RA stop him from having a full productive life.
A chronic disease characterized by the inflammation of the lining of the joints, which is called the synovium.
Affects 2.1 million Americans between the ages of 20 and 50, but also affects young children and adults over 50
More common in women than men.
Known as an autoimmune disease because the body’s immune system attacks the joint lining.
The exact cause of RA is unknown.
Suspected causes are:
White blood cells that normally protect the body, migrate to the joint cavity.
Synovium becomes inflammed and engorged with fluid, causing synovitis.
Lymphocytes, Macrophages, continue to enter the joint cavity and multiply, differentiate, and release inflammatory mediators, cytokines, leukotrienes, and prostaglandins.How does the immune system play a role in this disease
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