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Medical Application of Membrane in Drug Delivery System. NUR HIDAYAH OMAR SITI HAJAR ABU BAKAR ALIA ZULAIKHA MOHD HANIF. INTRODUCTION. Membrane technology is of major importance in medical applications

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medical application of membrane in drug delivery system

Medical Application of Membrane in Drug Delivery System




  • Membrane technology is of major importance in medical applications
  • Used in drug delivery, artificial organs, tissue regeneration, diagnostic devices, as coatings for medical devices, bioseparations, etc.
  • Delivery system is to deliver a drug to a specific site, in specific time and release pattern.
membrane based system
Membrane –based system
  • Membrane-based systems basically a drug reservoir is contained in a membrane device.

Two types of systems can be distinguished:

• Osmotic membrane systems.

• Diffusion controlled membrane systems.

osmotic membrane system
Osmotic Membrane System
  • Consists of a reservoir made of a polymeric membrane permeable to water but not to the drug (semi-permeable membrane).
  • The reservoir contains a concentrated drug solution. As water crosses the membrane due to osmotic pressure, the drug solution is released through the orifice.
diffusion controlled membrane syste m
Diffusion Controlled Membrane System
  • The drug release is controlled by transport of the drug across a membrane.
  • The transport is dependent on the drug diffusivity through the membrane and the thickness of the membrane
  • The membrane can be porous or non-porous and biodegradable or not.
  • An artificially-prepared vesicles composed of a lipid bilayer.
  • Used as a vehicle for administration of nutrients and pharmaceutical drugs.
  • Composed of natural phospholipids, and contain mixed lipid chains with surfactant properties
  • Liposomes vary in size due to their medication type like DNA, enzyme, drugs, and supplementation .
targeted delivery
Targeted delivery
  • Liposomes prepared from natural or synthetic phospholipids containing an encapsulated drug. This type of drug delivery reduces toxicity, maintains or enhances activity and facilitates accumulation in the disease site.
  • Conventional liposornes that incorporate lipids enhancing circulation lifetimes. Delivery in these molecules improves access to the disease site and reduces interaction with phagocytic cells of the reticulo-endothelial system.

Conventional liposomes with lipids that enhance circulation lifetimes and have

  • surface-associated targeting information. Drug delivery using this type of liposome results in an improved therapeutic index and target cell
  • specific delivery.
  • Examples; antibodies (glycolipids and mannose), proteins (e.g. Transferrin and asialofetuin) , and vitamins (e.g. folic acid have been used to target specific cells via cell surface receptors
  • Fusogenicliposomes with DOPE or fusogenic proteins. This method allows intracellular drug delivery.
  • DOPE has been particularly useful for cationic liposomescomplexed with plasmid DNA for gene delivery.
applications of m embrane system
Applications of Membrane System


  • The diffusion principle is applied to pills and tablets.
  • The drug is pressed into tablet which is coated with a non-digestible hydrophilic membrane.
  • Once this membrane gets hydrated, a viscous gel barrier is formed, through which the drug slowly diffuses.
  • The release rate of the drug is determined by the type of membrane used


  • consist of a membrane reservoir containing a drugin liquid or powder form
  • The drug slowly diffuses through the semi-permeable membrane and the rate of diffusion depends on the characteristics of both the drug and membrane.
  • The thickness of the membrane is constant to secure uniformity of drug delivery.

If the membrane degrades, drug delivery should be accomplished prior to membrane degradation.

  • If the membrane is made of non-degradable material, it should be surgically removed afterwards.
  • A drawback of implants is the risk of membrane rupture resulting in drug-dumping: a sudden release of large amounts of drugs


  • Patches are broadly used in drug delivery.
  • The most characteristic examples are ocular (eye) and transdermal patches.
  • Ocular patches are typical membrane-controlled reservoir systems. The drug, accompanied by carriers, is captured in a thin layer between two transparent, polymer membranes, which control the rate of the drug release

An annular white-coloured border is surrounding the reservoir for handling of the device.

  • The device is placed on the eye, where it floats on the tear film.
  • Through diffusion, the drug is directly administered to the target area.