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Granulomatous diseases

Granulomatous diseases. Dr Shaesta Naseem 13-10-12. Gross and histopathology. 1- Tuberculosis of the lung. Ghon’s Complex. Organ: lung Dx : Caseous necrosis (tuberculosis). Tuberculous Granulomas. Caseation Necrosis. Epitheloid cells in Granuloma.

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Granulomatous diseases

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  1. Granulomatous diseases DrShaestaNaseem 13-10-12

  2. Gross and histopathology

  3. 1- Tuberculosis of the lung

  4. Ghon’s Complex

  5. Organ: lung Dx : Caseous necrosis(tuberculosis)

  6. Tuberculous Granulomas

  7. Caseation Necrosis

  8. Epitheloid cells in Granuloma

  9. MORE ACID-FAST BACILLI, AFB

  10. Miliary tuberculosis of the lung : • Section of the lung shows : The alveolar septae contain many tubercles which consist of epithelioid cells , few langhan’s giant cells and peripheral rim of lymphocytes with or without caseation

  11. 2- Tuberculous lymphadenitis

  12. Tuberculous lymphadenitis :Section of a lymph node with connective tissue capsule and lymphoid tissue shows: • Many round and oval tubercles/ granulomas with or without central caseation that appears structureless, homogenous and pink in colour. • The granulomas consists of epithelioid cells, few langhan’s giant cells (large cell with multiple peripheral nuclei) and peripheral rim of lymphocytes.

  13. 3- Bilharziasis of the colon

  14. COLONIC BILHARZIASIS

  15. BILHARZIASIS (COLON)

  16. SCHISTOSOMIASIS OF THE URINARY BLADDER

  17. Bilharziasis of the rectum\urinary bladder:Section of fragments of rectal\urinary bladder mucosa shows: • Many Bilharzial ova with yellow brown shells in mucosa and submucosa surrounded by fibrosis and chronic inflammatory cells consisting of lymphocytes, plasma cells and many eosinophils. • Few granulomas are seen around the ova.

  18. 5- Cutaneousleishmaniasis

  19. Histological view shows marked cellular infiltration and parasites (Leishman bodies) within macrophages

  20. Picture shows a macrophage containing Leishmaniaamastigotes with characteristic features (round nucleus, rod-shaped kinetoplast; arrows) .

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