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NEW FACULTY ORIENTATION

NEW FACULTY ORIENTATION

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NEW FACULTY ORIENTATION

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  1. NEW FACULTY ORIENTATION Introduction to the UMSOM Research Enterprise Richard N. Pierson III, MD, FACS Senior Associate Dean for Academic Affairs Interim Director for Research Affairs October 23, 2012

  2. SOM Research Faculty Funding • Total Faculty Research Productivity • National Avg. $315K/PI • UMB Avg. $500K/PI; 8th most productive nationally • AAMC National Ranking • 5th among 76 public medical schools • 16th among 138 public and private medical schools • Total Grants and Contracts Expenditures

  3. NIH : Funding Profile of Current SOM Research Faculty • PROGRAM PROJECTS (5) • HYPERTENSION • CARDIAC SIGNALING • VASCULAR SIGNALING • MENTAL RETARDATION • ALTERNATIVE MEDICINE • CENTER GRANTS (5) • PSYCHIATRIC INTERVENTIONS • AGING • HEALTH DISPARITIES • NCI DESIGNATED CANCER CENTER • NUTRITION OBESITY RESEARCH

  4. NIH : Funding Profile of Current SOM Research Faculty • TRAINING GRANTS (16) • TOXICOLOGY/EPIDEMIOLOGY • CELLULAR NEUROSCIENCE • MEMBRANE BIOLOGY • IMMUNITY AND INFECTION • MUSCLE BIOLOGY • INTEGRATIVE NEUROSCIENCE • OROFACIAL BIOLOGY/NEUROSCIENCE • CARDIOVASCULAR CELL BIOLOGY • REHABILITATION RESEARCH • TRANSFUSION MEDICINE • CANCER BIOLOGY • VASCULAR BIOLOGY

  5. NIH : Funding Profile of Current SOM Research Faculty • TRAINING GRANTS/CLINICAL FIELDS • GASTROENTEROLOGY • SCHIZOPHRENIA • VACCINOLOGY • GERONTOLOGY/EXERCISE PHYSIOLOGY • TRAUMA • EPIDEMIOLOGY OF AGING • MEDICAL SCIENTIST (MD/PhD) • IN-PROGRESS • REPRODUCTIVE BIOLOGY • CHEMOSENSORY NEUROSCIENCE • MOLECULAR SIGNALING/STRUCTURE • MICROBIOLOGY/IMMUNITY

  6. SOM Organized Research Centers • Health Policy & Health Services Research • Integrative Medicine (CIM) • Mucosal Biology • Research on Aging • Shock, Trauma and Anesthesiology (STAR) • Stem Cell Biology & Regenerative Medicine • Vaccine Development (CVD) • Vascular and Inflammatory Diseases (CVID) • (Bioinformatics: in development)

  7. SOM Programs • Comparative Medicine (Vet. Resources) • Genetics and Genomic Medicine • Minority Health and Health Disparities • Neuroscience • Oncology • Personalized Medicine • Trauma

  8. Structural Biology Network • NMR Center (Center for Biomolecular Therapeutics) • X-ray Crystallography Core • Mass Spectrometry Core • Proteomics Core (SOM, SOP) • Edman Sequencing and Protein Analysis Core • BiaCoreCore Facility • Protein Production and Purification

  9. Drug Development Network • Pharmacokinetics Biopharmaceutical Laboratory • Industrial Pharmaceutics Laboratory • Clinical Pharmacology Unit • Center for Nanomedicine and Cellular Delivery • Computer Aided Drug Design • High-throughput Screening Core • Center for Biomolecular Therapeutics (SOM at Shady Grove)

  10. UM Institute of Human Virology (IHV) SOM Institutes* UM Institute for Genome Sciences (IGS) Dr. Claire Fraser Director, Institute for Genome Sciences Professor, Department of Medicine Robert Gallo, MD Director, Institute of Human Virology Professor, Department of Medicine * Excludes the newly established Clinical and Translation Science Institute (CTSI)

  11. Efforts to Enhance Research OpportunitiesOffice of Research Career Development Target Audiences: New Faculty (junior principle investigators) Post-doctoral research scientists First Priority - to develop workshops, classes and consultation services focusing on: - Writing a Competitive Grant Application - Revising a Grant Application - Individual mentoring - Identifying Funding Opportunities Wendy Sanders, Derek Haseltine, Stacy Small

  12. Basic and Clinical Resources Network • NICHD Brain/Tissue Bank for Developmental Disorders • Pathology Biorepository and Research Core • Maryland Psychiatric Research Center’s Brain Bank • Histology Core • Biostatistics Shared Resource (Epi/PH) • Informatics Resource Center • Pharmaceutical Research Computing • BIORESCO (Biomedical Research Supply Core)

  13. Support for Enhanced Clinical Research • Dept of Epidemiology/PH • Statistics, biocomputation, study design, mock review – (Jay Magaziner) • IRB (HRPO) - (Susan Buskirk) • CICERO: assistance with submission • Electronic systems submission -- • COEUS grant submissions review – (ORD) • Conflict of Interest review- (Nancy Lowitt) • IACUC protocol review (Peiser/Sacci) • Planned CTSA (GCRC, K12) (Davis/Shuldiner)

  14. Infrastructure to Enhance Research Environment • Genomics and other “omics” cores • Small Animal Physiology core • Vet services and facilities review • Animal Imaging Center (6 HH ) • 7T MRI, CT/PET, Ultrasound; TEM/SEM • Confocal microscopy (6 HH) • Flow Cytometry, sorting • GLP capability (Vet Med) • GCP (Personalized Medicine) • Dean’s office personnel and support for complex grant preparation, submission and management • Seed funding and Bridge funding

  15. UMB / UMCP Collaboration M-Power Maryland A new Institutional collaboration to maximize research and expertise across campuses for the benefit of the faculty, state and citizens of Maryland.

  16. UMB & UMCP Funding and Joint Seed Programs FY2012 Total Grant & Contract Funding UMB – approx. $ 500 million UMCP – approx. $ 500 million Significant Economic Impact for the State UMB-UMCP Joint Seed Program FY2007-2011 – Funded 38 grants totaling $2.8M New SEED programs in 2012 : CBT/IBBR ($300K) , CTSI ($150K) Important Resource for future federal and non-federal research proposals

  17. University of Maryland School of Medicine Available Core Facilities and Shared Resources Imaging Network Confocal Microscopy Electron Microscope Animal Imaging MRI Research Imaging Neuroimaging Structural Biology Network NMR X-Ray Crystallography Proteomics/Mass Spec. Biacore Edman Sequencing Clinical Resources Network Pathology Biorepository Brain & Tissue Banks Cytokine & Hormone Immunoassay Core Flow Cytometry Drug Development Network Pharmacokinetics/Biopharmaceutics Lab Industrial Pharmaceutics Lab Center for Nanomedicine and Cellular Delivery Computer-Aided Drug Design (CADD) High Throughput Screening Core Model Development Network Novel Model Systems Development Veterinary Services Translational Core Lab Small Animal Physiology Core Bioengineering & BioroboticsNetwork UMCP Genomics Network Biopolymer/Genomics Core Genomics Resource Center Biochemical Genetics Lab Cytogenetics Lab Translational Genetics Core

  18. Imaging Structural Biology Clinical Resources Drug Development Model Development Genomics

  19. NIH Construction Grant Space Renovations: BRB-7, HH and HSF1-6 • Renovations to BRB-7 will provide new space for research core facilities (Flow Cytometry, Mass Spectrometry, Biopolymer, Transgenic), Clinical Cytogeneics, and a CLIA-certified Personalized Genomics core with robotic sample archive. • Renovations to the 6 floor of HSF1 and HH will provide renovated research space for consolidated imaging cores (Electron Microscopy, Confocal Microscopy, in vivo animal imaging, MRI, PET-CT, ultrasound). • Anticipated completion date is summer, 2013.

  20. NIH Core Renovation and Consolidation Grant BRB-7 Renovations to BRB-7 include an open lab design for the north side (top), which will physically consolidate a number of existing core facilities such as Biopolymer, Transgenic, translational Lab, BIACore, Proteomics, and others. The south side (bottom), will allow development of new resources that will specifically support clinical and translational research. Estimated date for completion: August, 2012.

  21. NIH Core Renovation and Consolidation Grant BRB-6 Proposed renovations to BRB-6 will result in a comprehensive imaging suite between BRB and Howard Hall 6th floors. This will include Electron Microscopy, Confocal Microscopy and whole animal imaging (MRI, PET/CT).

  22. Research Environment - Space Management • Existing Space allocation: annual reassessments for productivity • Dry lab space: lease commercial building space • Wet lab space: renovate and repurpose labs • New HSF III (2018) – 178,000 NASF: Planning and Design started • Building and Leasing: UMB Biopark – Ongoing development potential

  23. Closing • Seek out the tools to help you advance • Manage the space available wisely • Use the expertise and collaborative spirit of the faculty to help guide you • Take advantage of all of these highly productive and leveraged resources for success • Communicate with mentors and peers often • Enjoy your experience in SOM and use your time well to contribute to the community