Chapter 4. Protein 3-Dimensional Structure and Function. Terminology. Conformation – spatial arrangement of atoms in a protein Native conformation – conformation of functional protein. Protein Classification. Simple – composed only of amino acid residues
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Protein 3-Dimensional Structure and Function
(metal ions, co-factors, lipids, carbohydrates)
Example: Hemoglobin – Heme
All H-bonds in the alpha-helix are oriented in the same direction giving the helix a dipole with the N-terminus being positive and the C-terminus being negative
One side of the helix (dark) has mostly hydrophobic AA’s
Two amphipathic helices can associate through hydrophobic interactions