EPI235: Epi Methods in HSR. April 12, 2007 L4 Evaluating Health Services using administrative data 3: Advanced Topics on Risk Adjustment and Sensitivity Analysis (Dr. Schneeweiss)
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Wang PS et al: J Am Geriatr Soc 2001
“… there are known knowns; there are things we know we know. We also know that there are known unknowns; that is to say we know that there are some things we do not know. But there are also unknown unknowns – the ones we don’t know we don’t know. …, it is the latter category that tend to be the difficult ones.”
(Wisely unknowing) Donald Rumsfeld
Hernan, Robins: Biometrics 1999
Wang et al: JAGS 2001;49:1685
Zolpidem use and hip fractures in older people.
Are there any unmeasured factors that may lead to a preferred prescribing of zolpidem to people at higher risk for falling and fracturing?
> Frailty is a hard to measure concept in claims data
Walker AM: Observation and Inference. Epidemiology Resources Inc., Newton, 1991
Psaty et al: JAGS 1999;47:749
CCB use and acute MI.
Are there any unmeasured factors that may lead to a preferred prescribing of CCB to people at higher risk for AMI?
ARR = 1.57
ARR = 1.30
Velentgas et al: PDS, under review
Schneeweiss et al: Epidemiology, in press 2004
Walker AM: Observation an Inference. Epidemiology Resources Inc., Newton, 1991
Obesity (BMI >=30 vs. BMI<30)
OTC aspirin use (y/n)