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overview biology of estrogen progesterone receptors

Important Issues. Roles of ERa and ERb Distinct Functions of PR-A and PR-B Selective Ligands (SERMs and SPRMs) Coregulators Interrelationships Between Estrogen and Progestin Hormone-Receptor Pathways Tissue Selectivity in Estrogen and Progestin Actions. . Target Tissues in Females

JasminFlorian
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overview biology of estrogen progesterone receptors

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    1. OVERVIEW Biology of Estrogen & Progesterone Receptors

    3. Target Tissues in Females & Males

    4. Estrogen Receptor in Breast Cancer

    5. New York Times, April 7, 1998, p. A1

    6. Tissue Selectivity

    9. Human Estrogen Receptors a and b Human Estrogen Receptors ? and ? Human Estrogen Receptors ? and ?

    10. Exquisite Precision in Receptor Regulation

    11. Ligands for Estrogen Receptors

    12. SERM Action

    13. Structures of Diethylstilbestrol-ERa LBD and Hydroxytamoxifen-ERa LBD

    14. PPT, an ERa Specific Ligand, Prevents Ovariectomy-Induced Loss of Bone Mineral Density

    15. PPT, an ERa Specific Ligand, Prevents Hot Flush in a Rat Model

    17. Estrogen Effects on Cell Cytoarchitecture

    19. Estrogen Receptor Beta

    20. ERb in Human Breast

    21. Of 37 genes stim by E2 - - A,B,C -- expected patterns D,E,F -- unusual patternsOf 37 genes stim by E2 - - A,B,C -- expected patterns D,E,F -- unusual patterns

    22. Comparative Patterns of Gene Stimulation by Estradiol and SERMs (MCF-7 Cells) [n = 33] TOT , considered the most estrogen-like SERMTOT , considered the most estrogen-like SERM

    23. SERM Antagonism of Estradiol Stimulation (MCF-7 Cells) [n = 35] Of 37 genes stim by E2 - - A,B,C -- expected patterns D,E,F -- unusual patternsOf 37 genes stim by E2 - - A,B,C -- expected patterns D,E,F -- unusual patterns

    24. Progesterone Receptor

    25. Ligands for Progesterone Receptor

    26. Human Progesterone Receptor: A and B Forms

    27. Human Progesterone Receptor Isoforms A and B

    28. Interrelationships Between Estrogen and Progestin Receptor Signaling Pathways

    29. Women’s Health Initiative (WHI) Clinical Trial

    30. Would outcome be different if:

    32. Take-Home Messages

    34. Questions that Remain

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