GBA1 Mutations and Associated Diseases

1. GBA1 Mutations and Associated Diseases • GBA1 mutations, causing lysosomal disorder Gaucher disease, are the main factor for genetic Parkinson disease and Dementia with Lewy Bodies (DLB). According to the study, many GBA1 mutations increase the risk of many diseases. The main example of GBA1 associated disease is Parkinson disease, a neurological movement disorder. The person suffering from Parkinson's disease finds it difficult to control body movement. In early stage, there are no major symptoms of the disease. But it can worsen with time as the condition progresses. The following symptoms can be seen in a person suffering from Parkinson disease: • Change in speech: When a person is suffering from Parkinson disease, he/she may speak soft or hesitate before taking to someone. • Change in writing: It becomes quite difficult for a person to write properly. • Rigid muscles: Muscles become stiff or rigid, which makes them painful and limits the range of motion. • Muscle twisting, cramps: A person may experience painful cramps in feet and clenched toes. • Tremor: Hands and arms begin to shake. In the early stage of the disease, patient's one part of the body or one limb is affected. It is advised not to panic as the disease worsens with stress.

2. Other symptoms of the Parkinson disease include: • Urinary problems • Depression and anxiety • Low blood pressure • Speech/vocal changes • Constipation • Decreased facial expressions • Hallucinations/delusions • Fatigue, change in weight • Sleeping disturbance • Skin and hair problems • Memory problems • Bladder problems. etc.

3. If you are looking for a trusted centre that can help you with GBA1 associated disease, visit, Gain Therapeutics. It is counted among the trusted and reliable firm redefining drug discovery with its SEE-Tx™ target identification platform. The team of experts spans neurodegenerative diseases, lysosomal storage disorders, prion disease treatment in USA. • How Parkinson’s disease is treated? • Though there is no proper treatment for the disease, but, proper medication can help the patient in recovering fast. Speech therapy, physical exercises, physiotherapy, etc. will surely help in curing walking, speaking, eating and swallowing problem. • What causes Parkinson’s disease? • There are two main factors that play major role in causing Parkinson’s disease. They are: • Genes: Scientists have studied, specific genetic mutations can be the cause of Parkinson's disease. They are inherited from parents to their children. • Environmental Triggers: When a person is exposed to toxics, virus or bacteria, the risk of Parkinson disease increases.

4. There are so many trusted and recognized health care centres having professionals that can help patients in receiving the best care and treatment. These experts include: physiatrists, cardiologists, dietitians, social workers, urologists, speech specialists, etc. If you are looking for one, visit, Gain Therapeutics, the Allosteric Drug Discovery firm in USA. The company was established in 2017 with the active support of its founders and institutional investors such as TiVenture, 3B Future Health Fund and VitaTech. It has been awarded funding support from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and The Silverstein Foundation for Parkinson’s with GBA. Manolo Bellotto, Ph. D professor has offered GBA program where he has explained Manolo Bellotto, Ph. D professor has offered GBA program where he has explained GBA1 associated diseases: Gaucher disease and Parkinson’s disease.