Use of Logic Relationships to Decipher Protein Network Organization Peter M. Bowers, Shawn J. Cokus, David Eisenberg, Todd O. Yeates. Presented by Krishna Balasubramanian. Contents. Introduction Background Method Used - LAPP Results Observations Conclusion Future Work. Introduction.
Use of Logic Relationshipsto Decipher ProteinNetwork OrganizationPeter M. Bowers, Shawn J. Cokus,David Eisenberg, Todd O. Yeates
Presented by Krishna Balasubramanian
Logical Relationships to determine presence/absence of Proteins
Example showing triplet andpairwise uncertaintycoefficients, U.
Section taken from a 3-D histogram that describes the frequency of observed logic relationships in which protein A of the triplet is annotated as belonging to the COG functional category N, cell motility.
Plot of the cumulative number of protein triplets recovered atan uncertainty coefficient score greater than a given threshold.
Number of identified triplets (U >0.6) for each of the eight logic function types for randomized(black) and real (gray) phylogenetic profiles.
50 highest scoring relationships (U > 0.75) involving proteins fromthe cell motility and intracellular trafficking and secretion functionalcategories.