Use of Logic Relationships to Decipher Protein Network Organization Peter M. Bowers, Shawn J. Cokus, David Eisenberg, Todd O. Yeates. Presented by Krishna Balasubramanian. Contents. Introduction Background Method Used - LAPP Results Observations Conclusion Future Work. Introduction.
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Use of Logic Relationshipsto Decipher ProteinNetwork OrganizationPeter M. Bowers, Shawn J. Cokus,David Eisenberg, Todd O. Yeates
Presented by Krishna Balasubramanian
Logical Relationships to determine presence/absence of Proteins
Example showing triplet andpairwise uncertaintycoefficients, U.
Section taken from a 3-D histogram that describes the frequency of observed logic relationships in which protein A of the triplet is annotated as belonging to the COG functional category N, cell motility.
Plot of the cumulative number of protein triplets recovered atan uncertainty coefficient score greater than a given threshold.
Number of identified triplets (U >0.6) for each of the eight logic function types for randomized(black) and real (gray) phylogenetic profiles.
50 highest scoring relationships (U > 0.75) involving proteins fromthe cell motility and intracellular trafficking and secretion functionalcategories.