1 / 35

Automatized Methods for Coregistration of PET and MR Brain Images Jonny Reichwald

Automatized Methods for Coregistration of PET and MR Brain Images Jonny Reichwald. The Synapse. A: axon, B: neurotransmitter 1, C: neurotransmitter 2,. D: synaptic cleft, E: synapse for neurotransmitter 2, F: dendrite. Radioisotopes Isotope Name Half-life (s.)

liv
Download Presentation

Automatized Methods for Coregistration of PET and MR Brain Images Jonny Reichwald

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Automatized Methods for Coregistration of PET and MR Brain ImagesJonny Reichwald

  2. The Synapse A: axon, B: neurotransmitter 1, C: neurotransmitter 2, D: synaptic cleft, E: synapse for neurotransmitter 2, F: dendrite.

  3. Radioisotopes Isotope Name Half-life (s.) [11C] Carbon-11 1223.0 [15O] Oxygen-15 122.24 [13N] Nitrogen-13 597.9 [18F] Flourine-18 6586.2

  4. A: a radioactive decay occurs which emits a positron. B: the positron collides with an electron and emits photons. C: The photons are detected by photomultipliers

  5. A: The decay emits photon pairs at ~ 180 degrees B: The ideal case of a decay resulting in the LOR D.

  6. PET image after reconstruction

  7. MR image

  8. Production of helmet

  9. PET scan

  10. Limiting factors • Resolution • Noise • Reconstruction • Coregistration • Modelling • Ligands

  11. Limiting factors • Resolution • Noise • Reconstruction • Coregistration • Modelling • Ligands

  12. Coregistration • Finding transform • Coregistration algorithms • Transform • Resampling

  13. Transform Models Rigid Body Affine Projective Curved

  14. Coregistration

  15. Coregistration • Manual • Landmarks • Intrinsic • Extrinsic • Image overlay • Automatic • AIR/SPM99 • With automatic skull-stripping • Mutual Information

  16. Voxel probability

  17. Entropy

  18. Kullback-Leibler distance

  19. Mutual Information

  20. PET-PET Registration After Before

  21. HistogramPET-PET Before After

  22. Interpolation • Nearest Neighbour • Linear • (Windowed) Sinc • Splines

  23. General Interpolation

  24. Nearest Neighbour

  25. Linear

  26. Sinc

  27. Splines

  28. Splines

  29. Splines

  30. Time Activity Curve

  31. TAC error

  32. AC-PC Alignment

  33. AC-PC Alignment

  34. Program Platform • Hba Irix • ECAT6 Solaris • ECAT7 Solaris • ImageJ Java compatible • SPM Matlab compatible • PMOD Java compatible

  35. Conclusion • Use splines or NN for interpolation • AC-PC alignment not important • SPM • PMOD

More Related