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P. aeruginosa

Céphalosporinase naturelle inductible. P. aeruginosa. PIP. TZP. FEP. TIC. CIP. MOX. CS. CAZ. TCC. ATM. OFX. K. CPO. CTX. FOS. CFS. LVX. IPM. SXT. GM. TM. NET. AN. 60%. P. aeruginosa. Résistances naturelles.

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P. aeruginosa

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  1. Céphalosporinase naturelle inductible P. aeruginosa PIP TZP FEP TIC CIP MOX CS CAZ TCC ATM OFX K CPO CTX FOS CFS LVX IPM SXT GM TM NET AN 60%

  2. P. aeruginosa Résistances naturelles

  3. Overexpression of an AmpC-type enzyme in P. aeruginosa

  4. Resistance to imipenem in P . aeruginosa • 10-15 %of the isolates

  5. P. aeruginosa Résistance à L’imipénème = perte porine Opr D2 15-20%

  6. P. aeruginosa Céphalosporinase hyperproduite 10-15%

  7. Les carbapénèmases (métallo-enzymes) • diffusion mondiale • augmentation du nombre de publications à ce sujet; épidémies • rapportées en France; Paris, Marseille, Nantes • rares ? Nordmann et al. Clin Microbiol Infect. 2002

  8. Sensibilité aux antibiotiques. P. aeruginosa, 1999-2001 29 409 isolats de P.aeruginosa ont été collectés entre 1999 et 2001 dans plus de 30 hôpitaux français : CH et CHU ( poster RICAI 2001 , P. Plésiat )

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