Trait and sex selection the arrival of non invasive prenatal genetic testing
This presentation is the property of its rightful owner.
Sponsored Links
1 / 20

Trait and Sex Selection: The Arrival of Non -Invasive Prenatal Genetic Testing PowerPoint PPT Presentation


  • 89 Views
  • Uploaded on
  • Presentation posted in: General

Trait and Sex Selection: The Arrival of Non -Invasive Prenatal Genetic Testing. Jaime King, JD, PhD University of California, Hastings College of the Law Tarrytown Meeting July 26, 2011. Contents of Maternal Blood Serum. Non-Invasive Prenatal Diagnosis. No Brave New World?.

Download Presentation

Trait and Sex Selection: The Arrival of Non -Invasive Prenatal Genetic Testing

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Trait and sex selection the arrival of non invasive prenatal genetic testing

Trait and Sex Selection: The Arrival of Non-Invasive Prenatal Genetic Testing

Jaime King, JD, PhD

University of California, Hastings College of the Law

Tarrytown Meeting

July 26, 2011


Contents of maternal blood serum

Contents of Maternal Blood Serum


Non invasive prenatal diagnosis

Non-Invasive Prenatal Diagnosis


No brave new world

No Brave New World?


Critical features of nipd

Critical Features of NIPD

  • Non-Invasive

  • Timing

  • Comparatively Less Expensive


Non invasive prenatal genetic diagnosis nipd

Non-Invasive Prenatal Genetic Diagnosis (NIPD)


Current prenatal genetic diagnosis

Current Prenatal Genetic Diagnosis

Amniocentesis

Chorionic Villus Sampling


Non invasive prenatal diagnostic testing timeline

Non-Invasive Prenatal Diagnostic Testing Timeline

  • 4-5 Weeks - Earliest Detection of cell free fetal DNA (cff DNA)

  • 7-9 Weeks - Commercial Sex Determination

  • 9 Weeks - Reliable Genetic Testing

  • 7-10 Weeks - Reliable Aneuploidy Testing


Current prenatal screening timeline

Current Prenatal Screening Timeline

Diagnostic Tests

- Chorionic Villus Sampling - 10-13 weeks

- Amniocentesis - 15+ weeks (preferred)

The California Prenatal Screening Program, Patient Booklet, March 2009


Costs

Costs

  • T21 – Steven Quake predicts testing costs will be ~ $300 for Down Syndrome.

  • Prenatal Screening ~ $200

  • Ultrasound ~$300

  • Amniocentesis and CVS ~ $1500


Non invasive early low cost high volume

Non-Invasive+Early+Low Cost = High Volume


Major uses

Major Uses

  • Sex Determination

  • Diagnosis of Fetal Blood Type

  • Detection of Fetal Aneuploidy

  • Diagnosis of Single Gene Disorders

  • Susceptibility to Multigene and Complex Genetic Disorders

  • Genome Wide Analysis


Initial implementation challenges

Initial Implementation Challenges


Who will offer nipd

Who will offer NIPD?

Physicians

Biotechnology Companies

Both?


Commercial sex detection

Commercial Sex Detection


What tests to offer

What Tests to Offer?


How to inform patients

How to Inform Patients?


2 step informed consent model

2 Step Informed Consent Model


Longer term implementation concerns

Longer Term Implementation Concerns

  • Routinization of Prenatal Genetic Testing

  • Regulating Reproductive Autonomy


Thank you

Thank You


  • Login