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January 23, 2007
4-1. Kirk Ziegler and Emil Unanue
Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes.
J. Immunol. 127:1869-1875. (1981).
“To avoid giving the impression of claiming that I was always right, I can provide an example wherein Time, the corrector upended my judgment. Several years ago, during my digression into immunology, I became involved in a controversy over antigen processing, the notion that foreign proteins must first be degraded inside a cell before they can be presented to T lymphocytes. One could say that I created the controversy by questioning whether the evidence available then warranted the universal acceptance of the antigen processing hypothesis and by claiming that our own data went against the hypothesis. On the latter point I was wrong. Antigen processing is now a well-established concept and Emil R. Unanue, Paul M. Allen, Howard M. Grey, Alain Townsend and others deserve all the credit for developing it. My attempt to deny antigen processing was perhaps my most spectacular, but not my only blunder. Nonetheless, I do not regret having challenged the antigen processing hypothesis, and if we had at hand today that knowledge which was available then, I would do so again...”
Jan Klein, Alone on the heart of the earth: an immunogeneticist’s journey into the past. Adv. Cancer Research 63: 1-39, 1994.
Therefore the consensus was that CD4 and CD8 T cells were recognizing antigens that distinct in source (virus vs bacteria) and cell location (membrane vs. soluble)
4-2. Lynda Morrison, Aaron Lukacher, Vivian Braciale, David Fan, and Tom Braciale
Differences in antigen presentation to MHC class I- and class II-restricted influenza virus-specific cytolytic T lymphocyte clones.
J. Exp. Med. 163:903-921. (1986).
4-3. Alain Townsend, Claes Öhlén, Judy Bastin, Hans-Gustaf Ljunggren, Linda Foster and Klas Kärre
Association of class I major histocompatibility heavy and light chains induced by viral peptides.
Nature 340:443-448. (1989).