1 / 15

Population Structure and History in Sub-Saharan Africa

Explore the rich genetic and linguistic diversity in Africa and its implications for the design of large-scale genomic studies and fine mapping. Discover the African Genome Variation Project, which aims to study genetic variation in Africa to inform African genomics research. Learn about population structure, admixture, and differentiations across various African regions and ethnicities. Understand how this information can be leveraged in the study of African genomics and its implications for epidemiological studies and fine mapping.

cherylm
Download Presentation

Population Structure and History in Sub-Saharan Africa

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Population Structure and History in Sub-Saharan Africa Manjinder Sandhu

  2. Why study genetic diversity in Africa? • Africa has the greatest genetic and linguistic diversity in the world • Genetic diversity has implications for the design of studies • Can large scale genomic studies be carried out across Africa? • Can we utilise population differentiation for fine mapping? • Can admixture mapping be used for certain traits?

  3. What is the African Genome Variation Project? • Study of 16 ethno-linguistic groups across SSA from populations relevant to medical genomics • 100 individuals with dense (2.5M) genotype data in each • Largest diversity panel from Africa so far • Aim: to study genetic variation in Africa to inform large scale studies in African genomics

  4. Population structure and admixture

  5. Eurasian cline YRI CEU

  6. Khoe-San cline YRI Juhoansi

  7. European and Khoe-San admixture in SSA South Africa Bantu Khoe-San West Central Africa West Africa North Africa East Central Africa East Africa K=2 K=3 K=4 K=5 K=6

  8. Population differentiation

  9. Confirming Eurasian and Khoe-San admixture

  10. Quantifying and dating admixture European admixture Khoe-San admixture

  11. European and HG admixture in SSA Khoe-San admixture European admixture

  12. Interpretation • Widespread European admixture in all SSA populations, dating to different time-points • Broadly consistent with demographic history • Hunter gatherer admixture seen in many SSA populations, particularly southern bantu populations • Dating consistent with the bantu expansion

  13. How can this information be leveraged in the study of African genomics • Most populations used for epidemiological studies in Sub-Saharan Africa are not very differentiated • Differentiation seems to arise largely from admixture rather than divergence or drift • Implications for large-scale genomic studies and fine mapping

  14. Next steps • Using admixture mapping of traits for phenotypically differentiated diseases between different populations • Understanding the relationship between admixture and LD structure in African populations in the context of fine mapping

  15. Acknowledgements

More Related