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Fat Subtypes and Breast Cancer Publication

Fat Subtypes and Breast Cancer Publication. Smith-Warner, S.A., et al. Types of dietary fat and breast cancer: a pooled analysis of cohort studies. International Journal of Cancer. 2001; 92: 767-774. Cohort Studies Included in the Pooled Analyses of Fat Subtypes and Breast Cancer.

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Fat Subtypes and Breast Cancer Publication

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  1. Fat Subtypes and Breast Cancer Publication Smith-Warner, S.A., et al. Types of dietary fat and breast cancer: a pooled analysis of cohort studies. International Journal of Cancer. 2001; 92: 767-774.

  2. Cohort Studies Included in the Pooled Analyses of Fat Subtypes and Breast Cancer Sweden Mammography Cohort Canadian National Breast Screening Study Nurses’ Health Study Netherlands Cohort Study New York University Women’s Health Study New York State Cohort Adventist Health Study Total = 351,821 # cases = 7,329 Iowa Women’s Health Study

  3. Cohort Studies Included in the Pooled Analyses of Fat Subtypes and Breast Cancer Study Total # of Cohort Cases Adventist Health 15,172 160 Canadian National 56,837 419 Iowa Women’s 34,406 1,130 Netherlands Cohort 62,412 887 NY State 18,475 367 NY University 14,006 385 Nurses’ Health (a) 89,046 1,020 Nurses’ Health (b) 68,817 1,638 Sweden Mammography 61,467 1,323 TOTAL 351,821 7,329 Smith-Warner, et al. 2001

  4. Range of Median Intakes in Control Participants Across Studies Type of Fat Range of Median Intakes (% kcal) Total 30-41 Saturated (SFAT) 10-16 Monounsaturated (MFAT) 11-16 Polyunsaturated (PFAT) 4-9 Animal (AFAT) 12-29 Vegetable (VFAT) 10-21 Smith-Warner, et al. 2001

  5. Pooled Multivariate Relative Risks of Breast Cancer for Different Dietary Fats Study RR (95% CI)* p-hetero. Total 1.00 (0.98-1.03) 0.19 Saturated 1.03 (0.95-1.10) 0.04 Monounsaturated 1.00 (0.94-1.07) 0.16 Polyunsaturated 1.01 (0.94-1.08) 0.48 Animal 1.00 (0.97-1.04) 0.08 Vegetable 1.01 (0.98-1.04) 0.15 * Increment = 5% kcal Each fat in a separate model. Smith-Warner, et al. 2001

  6. Study-Specific Relative Risks of Breast Cancer and Saturated Fat Adventist Canada Iowa Netherlands NY State NY University Nurses' (a) Nurses' (b) Sweden Combined .5 1 2 Relative Risk Smith-Warner, et al. 2001

  7. Study-Specific Relative Risks of Breast Cancer and Monounsaturated Fat Adventist Canada Iowa Netherlands NY State NY University Nurses' (a) Nurses' (b) Sweden Combined .5 1 2.5 Relative Risk Smith-Warner, et al. 2001

  8. Study-Specific Relative Risks of Breast Cancer and Polyunsaturated Fat Adventist Canada Iowa Netherlands NY State NY University Nurses' (a) Nurses' (b) Sweden Combined .5 1 2.5 Relative Risk Smith-Warner, et al. 2001

  9. Study-Specific Relative Risks of Breast Cancer and Animal Fat Adventist Canada Iowa Netherlands NY State NY University Nurses' (a) Nurses' (b) Combined .67 1.5 Relative Risk Smith-Warner, et al. 2001

  10. Study-Specific Relative Risks of Breast Cancer and Vegetable Fat Adventist Canada Iowa Netherlands NY State NY University Nurses' (a) Nurses' (b) Combined .67 1.5 Relative Risk Smith-Warner, et al. 2001

  11. Pooled Mutually Adjusted Relative Risks of Breast Cancer Type of fat RR (95% CI)* p-hetero. Saturated 1.09 (1.00-1.19) 0.25 Monounsaturated 0.93 (0.84-1.03) 0.34 Polyunsaturated 1.05 (0.96-1.16) 0.58 * Increment = 5% kcal All three fats included in the same model Smith-Warner, et al. 2001

  12. Pooled Mutually Adjusted Relative Risks of Breast Cancer Substitution RR (95% CI)* Sat. for Mono. 1.18 (0.99-1.42) Sat. for Poly. 0.98 (0.85-1.12) Mono. for Poly. 0.87 (0.73-1.02) * Increment = 5% kcal Smith-Warner, et al. 2001

  13. Cross-Classified AnalysesMFAT-SFAT # Cases RR (95% CI) Low SFAT, High MFAT 45 1.00 (ref) Other combinations 6649 1.06 (0.77-1.45) High SFAT, Low MFAT 50 1.06 (0.68-1.65) Smith-Warner, et al. 2001

  14. Pooled Mutually Adjusted Multivariate Relative Risks of Breast Cancer by Menopausal Status Fat Group RR (95% CI)* p-for- inter. SFAT Premeno. 1.10 (0.91-1.35) Postmeno. 1.07 (0.93-1.24) 0.61 MFAT Premeno. 0.87 (0.63-1.19) Postmeno. 0.81 (0.65-1.03) 0.46 PFAT Premeno. 1.12 (0.88-1.41) Postmeno. 1.28 (0.96-1.69) 0.72 *Increment=5% kcal Smith-Warner, et al. 2001

  15. Pooled Mutually Adjusted Relative Risks of Breast Cancer Type of fat RR (95% CI)* p-hetero. Animal 1.01 (0.96-1.06) 0.05 Vegetable 1.01 (0.98-1.04) 0.71 * Increment = 5% kcal Both fats included in the same model Smith-Warner, et al. 2001

  16. Pooled Mutually Adjusted Multivariate Relative Risks of Breast Cancer by Menopausal Status RR (95% CI)* p-for- interaction Animal fat Premeno. 1.01 (0.91-1.12) Postmeno. 0.99 (0.95-1.03) 0.93 Vegetable fat Premeno. 1.03 (0.93-1.13) Postmeno. 0.99 (0.94-1.04) 0.54 *Increment = 5% kcal Smith-Warner, et al. 2001

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