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Pulpal and periapical immune responses to infection

Pulpal and periapical immune responses to infection . There is no evidence that necrotic pulp tissue per se can elicit periapical inflammation, in the absence of bacteria. Moller & Fabricius 1981. No apical inflammation. 26 bacteria-free . 7 months. 78 monkey teeth with

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Pulpal and periapical immune responses to infection

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  1. Pulpal and periapical immune responsesto infection

  2. There is no evidence that necrotic pulp tissue per se can elicit periapical inflammation, in the absence of bacteria.

  3. Moller & Fabricius 1981 No apical inflammation 26 bacteria-free 7 months 78 monkey teeth with aseptically necrotized pulps 52 bacteria infected Apical periodontitis

  4. Periapical responses to pulpal infection

  5. + IL-2 Bacterial products IL-1, IL-6 TNFα PGE MF MHC-II Th IL-1 IL-2 Ag B Periapical inflammation and bone destruction

  6. Epithelial plugs Antibodies Periradicular lesions - barrier products Microbial Complement PMNs Microorganisms Granulomatous tissue Defence elements Very few endodontopathogens can advance through the barrier.

  7. Extraradicular microorganisms • Abscessed AP • Actinomyces spp, Propionibacterium propionicum • Infected radicular cysts • Infected material displaced into the periapical tissues Possible factor in the failure of the endodontic therapy.

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