1 / 25

Chem 509 Signal Transduction Winter 2012

Chem 509 Signal Transduction Winter 2012. Lecture 2. What difference between Gs, Gq and Gi?: Gs, G protein that is stimulatory and binds AC Gq, G protein that is stimulatory and binds PLC Gi, G protein that is inhibitory and binds AC. Phosphatidylinositol. Phosphatidylinositol-diphosphate.

zonta
Download Presentation

Chem 509 Signal Transduction Winter 2012

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Chem 509 • Signal Transduction • Winter 2012 Lecture 2

  2. What difference between Gs, Gq and Gi?: • Gs, G protein that is stimulatory and binds AC • Gq, G protein that is stimulatory and binds PLC • Gi, G protein that is inhibitory and binds AC.

  3. Phosphatidylinositol Phosphatidylinositol-diphosphate

  4. Phospholipases Phospholipase A1-can hydrolyze the sn-1 acyl bond but can also hydrolyse the sn-2 acyl bond. In the former case, this liberates a fatty acid and 2-acyl-glycerophospholipid.

  5. Phospholipases Phospholipase A­2-hydrolyzes the sn-2 acyl bond. This liberates a fatty acid and a lysophospholipid (1-acyl-glycerophospholipid)

  6. Phospholipases Phospholipase C-hydrolyzes one phosphoester bond to generate diacyglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).

  7. Phospholipases Phospholipase D-will hydrolyse the other phosphoester bond to generate phosphatidic acid (amphiphilic product) and inositol 4,5 diphosphate (IP2).

  8. PI=Phosphatidylinositol, Phosphorylated derivatives of PI are denoted as PIPx. PC=Phosphatidylcholine PA=Phosphatidic acid Lyso PC= deacylated phosphatidylcholine

  9. Calmodulin

  10. End of GPCR lecture story • Begin insulin signaling story

  11. Insulin signaling

  12. Insulin signaling

  13. Other Receptor Tyrosine Kinase Receptors

  14. Adaptation of insulin-mediated growth signal

  15. Brief overview of cancer signaling pathways

  16. Cell cycle

More Related