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Chem 509 Signal Transduction Winter 2012. Lecture 2. What difference between Gs, Gq and Gi?: Gs, G protein that is stimulatory and binds AC Gq, G protein that is stimulatory and binds PLC Gi, G protein that is inhibitory and binds AC. Phosphatidylinositol. Phosphatidylinositol-diphosphate.

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Chem 509 signal transduction winter 2012

  • Chem 509

  • Signal Transduction

  • Winter 2012

Lecture 2


Chem 509 signal transduction winter 2012


Chem 509 signal transduction winter 2012

Phosphatidylinositol-diphosphate


Chem 509 signal transduction winter 2012

Phospholipase A1-can hydrolyze the sn-1 acyl bond but can also

hydrolyse the sn-2 acyl bond. In the former case, this

liberates a fatty acid and 2-acyl-glycerophospholipid.


Chem 509 signal transduction winter 2012

Phospholipase A­2-hydrolyzes the sn-2 acyl bond.

This liberates a fatty acid and a lysophospholipid

(1-acyl-glycerophospholipid)


Chem 509 signal transduction winter 2012

Phospholipase C-hydrolyzes one phosphoester bond to generate

diacyglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).


Chem 509 signal transduction winter 2012

Phospholipase D-will hydrolyse the other phosphoester bond to generate

phosphatidic acid (amphiphilic product) and

inositol 4,5 diphosphate (IP2).


Chem 509 signal transduction winter 2012

PI=Phosphatidylinositol, Phosphorylated derivatives of PI are denoted as PIPx.

PC=Phosphatidylcholine

PA=Phosphatidic acid

Lyso PC= deacylated phosphatidylcholine


Chem 509 signal transduction winter 2012

Calmodulin are denoted as PIPx.


Chem 509 signal transduction winter 2012


Chem 509 signal transduction winter 2012

Insulin signaling are denoted as PIPx.


Chem 509 signal transduction winter 2012

Insulin signaling are denoted as PIPx.





Chem 509 signal transduction winter 2012

Cell cycle are denoted as PIPx.