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Chem 509 Signal Transduction Winter 2010

Chem 509 Signal Transduction Winter 2010. Lecture 6 Oguchi’s disease and preparation for final exam. Oguchi’s disease-Stationary Night Blindness. Defect found on chromosome 2q31.7 (location of arrestin) Defect found on chromosome 13q.34 (location of rhodpsin kinase)

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Chem 509 Signal Transduction Winter 2010

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  1. Chem 509 • Signal Transduction • Winter 2010 Lecture 6 Oguchi’s disease and preparation for final exam

  2. Oguchi’s disease-Stationary Night Blindness • Defect found on chromosome 2q31.7 (location of arrestin) • Defect found on chromosome 13q.34 (location of rhodpsin kinase) • Found more frequently in Japanese population. • Symptoms: 1) hemeralopia – unable to see in bright light. • 2) Yellow coloration of fundus (back of eye)

  3. Bioluminescence imaging http://images.google.com/imgres?imgurl=http://main.uab.edu/sites/drtc/documents/50236.JPG&imgrefurl=http://main.uab.edu/Sites/drtc/50232/bunnie/&usg=__amvWpYQ4G6 dcGZuJk3pj4oOuNcQ=&h=727&w=959&sz=86&hl=en&start=4&um=1&itbs=1&tbnid=L U6tkjTOq0UeVM:&tbnh=112&tbnw=148&prev=/images%3Fq%3Dbioluminescence%2Bimaging%2Bprocedure%26um%3D1%26hl%3Den%26tbs%3Disch:1

  4. Preparation for the final exam • Logistics • Material covered • How to study • Review

  5. Prep for Final-Logistics • Go to my website: • http://www.calstatela.edu/faculty/jmomand/SyllabiPage.html?Submit6=Course+syllabi • Look for Chem 509 final. Open link. Print document. • Answer questions longhand in CSULA blue book. Only use 1 blue book to answer questions. • Final Exam will be available Monday, Mar. 15 at 3 pm. • Must return Final Exam to me at LKH 270 by Thursday, Mar. 18 at 10 am. • Your answers should be in your own words.

  6. Prep for Final-Material Covered • Seven synopsis papers • Chapter 12 of Nelson and Cox, 2008 edition. • Lecture material

  7. Prep for Final-How to study • Understand the material on Chem 509 review sheet-at a minimum. • Understand how all the experiments were conducted in the synopsis papers. • Have knowledge of the signaling pathways discussed during lectures and in the synopsis papers. • Read Chapter 12 from Nelson and Cox, 2008. • Be able to answer the following questions in the back of Chapter 12: 1, 2, 3, 4, 5, 6, 10, 11, 13, 18a, 19, 20, 23. Be able to answer these questions and permutations of these questions. • Make sure you can create and interpret Scatchard plots.

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