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Signal Transduction

Signal Transduction. Channels Enzyme-linked receptors Receptor tyrosine kinases Tyrosine kinase associated receptors Receptor tyrosine phosphatases Transmembrane receptor S/T kinases Transmembrane guanyl cyclase G-proteins. Channels. Voltage-gated Ligand-gated Mechanosensitive.

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Signal Transduction

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  1. Signal Transduction • Channels • Enzyme-linked receptors • Receptor tyrosine kinases • Tyrosine kinase associated receptors • Receptor tyrosine phosphatases • Transmembrane receptor S/T kinases • Transmembrane guanyl cyclase • G-proteins

  2. Channels • Voltage-gated • Ligand-gated • Mechanosensitive

  3. Allosteric effectors of protein structure/function

  4. Mechanosensitive channels • MscS

  5. Conserved channel architecture

  6. How does it work?

  7. Tyrosine kinases

  8. Insulin-mediated cascade

  9. Small protein modules as signal adaptors

  10. SH2 and SH3 motifs

  11. SH3 domain binding

  12. The multi-domain structure of enzymes

  13. What happens to this enzyme when SH3 finds a partner?

  14. Notice the change in the linker…

  15. G-proteins

  16. Nucleotide hydrolysis as a timing mechanism

  17. Metals can be essential

  18. Conformational changes drive cycling between GTP-GDP bound states

  19. Inferring mechanism from structure

  20. Catalytic mechanism

  21. Ga binds to Gbg

  22. Gbg is has a propellar structure

  23. This interaction is regulated by other proteins

  24. One result of signal transduction

  25. Protein kinase A activation

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