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Exploring Life's Mysteries: From Replication to Evolution

Dive into the fascinating world of biology, from the growth and replication of organisms to the intriguing concept of prions and the mysteries of evolution. Discover the key elements of life, the history of life on Earth, and the scales of biology, from microscopic viruses to multi-cellular organisms. Explore the common descent of all life forms and ponder the possibility of life elsewhere in the universe. Delve into the science of life and unlock its secrets through exercises and homework that challenge your understanding of the complexities of living organisms.

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Exploring Life's Mysteries: From Replication to Evolution

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  1. Biology: the science of life Freaky sea-vent worms What is life?

  2. Growth and replication prions? computer algorithms nucleation = replication? aluminum potassium sulfatecrystallization What’s missing?

  3. Evolution Three keys: reproduction, variation, selection Improved replicator Neutral variant replicator Improved replicator Life:Reproduction + evolution

  4. Implementing life (physics + chemistry) • Encapsulation and individuality • Reproduction • Energy and material processing(metabolism) • Information storage • Environmental response

  5. Life elsewhere? • Liquid solvent (water) • Mars, Europa, Titan (methane and ethane)

  6. Our one data point: Life on Earth

  7. You are here Common descent Genetic and morphological evidence are consistent withall life on Earth sharing common ancestry

  8. History of life on Earth Humans arose very recently (roughly 200,000 years ago). Do this as in-class exercise Microscopic life dominates the history of Earth.

  9. Scales in biology

  10. Tobacco mosaic virus Have them adding scales 3x10-7 m in length, 1.8x10-8 m in width ~7x10-20 kg in mass ~6.4x103 bases in genome (single-strand RNA)

  11. Escherichia coli prokaryotic: no cell nucleus ~3x10-6 m in length ~7x10-16 kg in mass ~5x106 base pairs in genome

  12. Saccharomyces cerevisiae eukaryotic: cell nucleus ~5x10-6 m in diameter ~6x10-14 kg in mass ~5x106 base pairs in genome

  13. Arabidopsis thaliana multi-cellular plant ~0.2m in height ~1.2x108 base pairs in genome

  14. Drosophila melanogaster multi-cellular insect ~3x10-7 kg in mass (dry) ~1.2x108 base pairs in genome

  15. Mus musculus multi-cellular ~3.5x10-2 kg in mass ~3.4x109 base pairs in genome

  16. HeLa cell human immortal cell line ~25x10-6 m in diameter ~3.1x109 base pairs in genome

  17. Exercise: How many cells in your body? Exercise: How many bacterial cells in your gut?

  18. Homework How far apart are proteins in E coli? How long (physically) is the human genome? How does that compare to the size of a typical cell?

  19. Darwin: First Notebook on Transmutation of Species (1837)

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