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The helical tetramer of RIG-I 2CARD utilizes the upper surface of the second CARD to engage with MAVS CARD, facilitating MAVS filament creation. Research by Peisley et al., published in Nature in 2014.
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The helical tetramer of RIG-I 2CARD uses the top surface of the second CARD to interact with MAVS CARD and promote MAVS filament formation. A Peisleyet al. Nature 000, 1-5 (2014) doi:10.1038/nature13140