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Extracellular pH and bone cell function

pH  7.0. pH  7.0. pH  7.4. pH  7.2. pH  7.2. N O R M A L T I S S S U E S B L O O D A C I D O S I S. N O R M A L T I S S S U E S B L O O D A C I D O S I S. T I S S S U E A C I D O S I S. T I S S S U E A C I D O S I S. B L O O D. osteoblasts. osteoblasts.

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Extracellular pH and bone cell function

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  1. pH  7.0 pH  7.0 pH  7.4 pH  7.2 pH  7.2 N O R M A L T I S S S U E S B L O O D A C I D O S I S N O R M A L T I S S S U E S B L O O D A C I D O S I S T I S S S U E A C I D O S I S T I S S S U E A C I D O S I S B L O O D osteoblasts osteoblasts osteoblasts bone loss, no mineralisation bone loss, no mineralisation bone loss, no mineralisation net bone formation bone maintenance net bone formation net bone formation bone maintenance bone maintenance Ca2+  PO43- OH- Ca2+  PO43- OH- Ca2+  PO43- OH- Ca2+  PO43- OH- Ca2+  PO43- OH- Ca2+  PO43- OH- osteoclasts osteoclasts osteoclasts active osteoblasts mineralised bone matrix unmineralised bone matrix pre-existing bone inactive osteoclast active osteoclast Extracellular pH and bone cell function

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