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Molecule of the Week ATP Synthase

Molecule of the Week ATP Synthase. ...a nanoscale machine. Two molecular motors / generators Enzyme Ion pump. Function: Synthesize ATP / Create proton gradient. ATP – Adenosine triphosphate. Cellular energy „currency“ DNA replication / transcription Cell signalling. ADP + P i → ATP.

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Molecule of the Week ATP Synthase

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  1. Molecule of the Week ATP Synthase

  2. ...a nanoscale machine • Two molecular motors / generators • Enzyme • Ion pump Function:Synthesize ATP /Create proton gradient

  3. ATP – Adenosine triphosphate • Cellular energy „currency“ • DNA replication / transcription • Cell signalling

  4. ADP + Pi→ ATP

  5. ATP – Production • Photosynthesis

  6. ATP – Production • Photosynthesis • Aerobic respiration

  7. ATP – Production • Photosynthesis • Aerobic respiration • Anaerobic respiration

  8. Structure determination of F1 • “Structure at 2.8 Å resolution of F1-ATPase from bovine heart mitochondria”,Abrahams, Leslie, Lutter and Walker,Nature Vol. 370, 1994 • Boyer and Walker shared half of the 1997 Nobel Prize in Chemistry

  9. Molecular structure Cell membrane Inside cell organelle Diameter: 9 nm

  10. FO part

  11. FO part Ion motor

  12. F1 part

  13. F1 part

  14. F1 part

  15. F1 part Binding change / „Flip-flop“ mechanism

  16. F1 part Binding change / „Flip-flop“ mechanism

  17. Questions ?

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