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HMG CoA synthase

HMG CoA synthase. Philip A. Miller. Sequence. Mevalonate Pathway. Overall Structural Picture. Kinetics. - Difference in Rates with Mutation of Ala110Gly. Function. Electron density of the Catalytic loop. Important Amino Acids and their roles . Specific Amino Acid I ntegrations.

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HMG CoA synthase

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  1. HMG CoA synthase Philip A. Miller

  2. Sequence

  3. Mevalonate Pathway

  4. Overall Structural Picture

  5. Kinetics - Difference in Rates with Mutation of Ala110Gly

  6. Function

  7. Electron density of the Catalytic loop

  8. Important Amino Acids and their roles

  9. Specific Amino Acid Integrations

  10. Disease/Infection • Possibility of inhibitors for Mevalonate pathway would serve great as an antibacterial specific for pathogens • Such as Entherococcusfaecalis, Streptococcuspneumoniae, and Staphylococcus aureus • Common infections from trauma or surgical procedures • Specifically targets pathogenic bacterial, significantly more effective than commonly used broad-spectrum antibiotics

  11. Multiple sequence Alignment

  12. References: • Steussy, C., Robison, A.,Tetrick, A., Knight, J., Rodwell, V., Stauggacher, C., Sutherlin, A., (2006) A Structural Limitation on Enzyme Activity: The Case of HMG-CoA Synthase, Biochemistry • Stuessy, C., Vartia, A., Burgner, J., Sutherlin, A., Rodwell, V., Stauffacher, C., (2005) Biochemistry • Sutherlin, A., Hedl, M., Sanchez-Neri, B., Burgner, J., Stauffacher, C., and Rodwell, V. (2002) Journal of Bacteriology • Branden, Carl. Introduction to Protein StructureGarland Publishing, 1991. • Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K., and watson J. D. (1989) Molecular Biology of the Cell, Garland Publishing, New York

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