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Epigenomics in Plants: Understanding DNA Methylation and Transposable Elements

This lecture delves into the intricate world of epigenomics in plants, focusing on how methylation of DNA and histones plays a crucial role in transcriptional regulation. It explores the correlations between DNA methylation, histone modifications, and gene expression changes, as well as the regulation of transposable elements (TEs) and their transposition. The discussion includes insights into the enzymology of DNA methylation, the significance of repeat-associated DNA, and a proposed model for the epigenetic control of TE-host coevolution in response to biotic and abiotic stresses.

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Epigenomics in Plants: Understanding DNA Methylation and Transposable Elements

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  1. Lecture19–Epigenomics – Plants BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

  2. Epigenetics – Stable, but expression-related changes in gene function • Methylation of DNA & Histones is involved in epigenetic transcriptional regulation • Correlation between DNA methylation and histone modification • Correlation between gene expression changes and DNA Methylation • Transposable elements are regulated by DNA Methylation • Correlation between DNA Methylation and TE transposition • How is DNA methylation mediated? • Enzymology known • Transposable elements part of repeat-associated/heterochromatic DNA in the genome • Repeat associated DNA methylation controls “transposase” function that mediates transposition, and thus, epigenetic “inheritance”

  3. Plant Biotic and Abiotic Stress Responses • Old time work • Epigenetic stuff • State of the Art

  4. Epigenetic Regulation of Transcription and Transposition Bucher et al., (2012) Current Opinion in Plant Biology 15 (5): 503-510

  5. Stress Regulated Epigenenic Gene Regulation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  6. Proposed model for Epigenetic Control of TE-host coevolution Bucher et al., (2012) Current Opinion in Plant Biology 15 (5): 503-510

  7. Transducers Second Messengers I J.R., and Pikaard, C.S. 2011. Nature Reviews Molecular Cell Biology 12:483–492.

  8. CSB Fig 02:01 Cell signalling pathways J.R., and Pikaard, C.S. 2011. Nature Reviews Molecular Cell Biology 12:483–492.

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