1 / 5

TRANSMITTERS

TRANSMITTERS a. Ionotropic (channel-linked) receptors: transmitter binds to binding site at ion channel (receptor coupled to channel) b. Metabotropic (G-protein linked) receptors: 1. Receptor activates G-protein » alpha subunit splits off » binds to ion channel.

wilson
Download Presentation

TRANSMITTERS

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. TRANSMITTERS a. Ionotropic (channel-linked) receptors: transmitter binds to binding site at ion channel (receptor coupled to channel) b. Metabotropic (G-protein linked) receptors: 1. Receptor activates G-protein » alpha subunit splits off » binds to ion channel. 2. Receptor activates G-protein » alpha subunit splits off » activates enzyme » enzyme produces 2nd messenger (e.g. cAMP) » 2nd messenger changes ion channel ( more common )

  2. Metabotropic (G-protein linked):

  3. TRANSMITTERS Acetylcholine (ACh): - nicotinic receptor (ionotropic) - muscarinic receptor (metabotropic) AChE= acetylcholine esterase Monoamines: - DA, NE, E » catecholamines - Serotonin (5-HT) » indolamine - Monoamine oxidase (MAO) - 5 DA receptors » all metabotropic - D1 » increases cAMP (2nd messenger) - D2 » decreases cAMP - 4 NE receptors » all metabotropic (cAMP) - œ1, œ2, ß1, ß2 - 7 5-HT receptors » 6 metabotropic cAMP= cyclic adenosine monophosphate

  4. TRANSMITTERS Amino acids: Glutamate » NMDA, AMPA, Kainate -ionotropic Metabotropic 1 or 2 Glycine GABA a,b a=ionotropic, b=metabotropic. GABA a » 3 subtypes - affinity for GABA only - GABA + benzodiazepines - GABA + barbiturates +ETOH Neuropeptides » Enkephalins, Endorphins, etc. Nitric oxide (NO) - retrograde messenger

  5. from Pinel text L-DOPA PCPA-5HT; (tryptophan) Physostigmine - AChE Reserpine-5HT Amphet, Cocaine - DA Botulinum toxin - ACh Cocaine - DA Apomorphine - DA Amphet-NE, Morph-End Prozac - 5HT Atropine,curare » Ach Thorazine - DA (anti-psychotic)

More Related