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Infection. Tumors Grafts. Specificity Memory “Tolerance“. IMMUNITY. “innate resistance“ > 95 % Ab in eggs protective memory via Ab (vaccines) TB: no vaccine autoimmunity > 30 y, female > male 5 : 1. B cell – Ab responses. local mucosal IgA no T / LN / Peyer

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infection
Infection

Tumors

Grafts

Specificity

Memory

“Tolerance“

immunity
IMMUNITY
  • “innate resistance“ > 95 %
  • Ab in eggs
  • protective memory via Ab (vaccines)
  • TB: no vaccine
  • autoimmunity > 30 y, female > male 5 : 1
b cell ab responses
B cell – Ab responses
  • local mucosal IgAno T / LN / Peyer
  • Ag + LPS : IgM(no TH)
  • intact virus : IgM (no TH)
  • serotypes
  • monomeric Ag : obligatory TH
slide13

reverse genetic glycoprotein exchange between LCMV and VSV

rLCMV/INDG

rVSV/LCMV-GP

glycoprotein:IND-G

glycoprotein: LCMV-GP

LCMV

VSV-IND

glycoprotein: LCMV-GP

glycoprotein:IND-G

immunological memory quicker earlier greater better responses
Immunological memoryQuicker (earlier) Greater (better) responses

Immunity

Protection against disease by reinfection

First infection kills host:

No memory needed

Host survives first infection:

Memory not needed neither

slide17

No protection by Memory B cells but protection by immune serum in IFN-aBR_/_ against VSV

Anti-VSV

neutr. AB

< 1 : 40

< 1 : 40

< 1 : 2500

% Survivors

0

0

100

VSVIND immune

spleen cells T+B

LCMV immune

spleen cells

VSVIND Ab

maintenance of protection
Maintenance of protection

1. Agent persists: TB, leprosy, HIV, HCV, LCMV

Herpes viruses

crippled: measles

2. Repetitive inf.: polio, bact. toxins

3. Antibody-antigen complex depots in lymph nodes and spleens

vaccines success pox polio igg measles mumps iga igg no success tb leprosy hiv ig t cells
Vaccines

Successpox, polio:IgGmeasles, mumps: IgA, IgG

No successTB, leprosy, HIV: Ig + T cells

memory pregnant female
Memory / Pregnant Female
  • Academic: earlier + higher (AG –)
  • Immune against cytopathic infectionsotherwise abortions / malformations
  • MHC-incompatibility – offspringmother: imm. suppr. / offspr.: imm. incomp.
  • Maternal antibodies attenuate acute infectionsphysiological vaccinations (incl. malaria, eggs)
  • Non-cytophatic infections transferred via placenta / at birth / after birth (LCMV, HCV, Herpes)
  • Resistance via T cells: HIV, HTV, TB Lepr. slow
  • "Emerging" infections
slide27

Peripheral

solid organs

Peripheral

lymphatic

organs

Generalized

hematogenic

spread

Imm. resp.

Exempl.

Ignor.

Papill. V

perif. self

Protect.

Polio V

Infl.

Antigen dose

Infect.

imm.

TB, HBV,

HIV

Exhaust.

deletion

HCV, LDV

(HIV, LCMV)

7 >100

7 >100

7 >100

Time of antigen availability (days)

h hengartner
A. Althage

M. Bachmann

Th. Kündig

A. Ciurea

U. Karrer

Hunziker

Recher

Pinschewer

C. de la Torre

H. Hengartner
  • A. Ochsenbein
  • B. Ludewig
  • M. Pericin
  • HP. Roost
  • St. Freigang
  • M. Martinic
  • Th. Rülicke
  • Odermatt
  • M. Whitt