McLean Hospital Research Town Meeting September 28, 2011

1. McLean Hospital Research Town Meeting September 28, 2011

2. AGENDA • Research Vision (Rauch) • Research Administration Process Improvement (Paskevich) • Research Metrics for FY11 (Paskevich) • IRB Update (Kaufman) • Email Migration to Partners Exchange Server • Q&A / Open Forum (Paskevich) • Presentation of the Anne M. Cataldo Excellence in Mentoring Award* (Rauch, Greenfield) * Reception from 2 pm to 3 pm will follow

3. McLean Hospital Research Vision Research Town Meeting September 28, 2011 3

4. McLean Hospital Charge to Research Vision Committee • Establish a scientific and research vision for McLean • Identify how best to realize this vision • What is needed to: • Sustain current investigators • Develop junior investigators • Recruit new investigators • Assess and facilitate collaborative opportunities • Critical infrastructure needs • Domains for investment 4

5. McLean Hospital Research Vision Committee • Developed a research mission statement • Evaluated McLean research program’s strengths, weaknesses, opportunities and threats • Considered a range of institutional research metrics, including those related to research impact • Reviewed fiscal context of McLean research program • Examined models of faculty support • Reviewed faculty recruitment processes & opportunities 5

6. McLean Hospital Research Mission Statement The McLean Hospital Research Community is committed to a full range of basic and clinical scientific inquiry. We will study the brain and behavior in both healthy and diseased states in order to build an improved knowledge base that can be rapidly and safely translated to improved patient care. We will promote an environment that is conducive to discovery, innovation, and teamwork. Through our research, we will train the next generation of leaders in psychiatry, mental health, and neuroscience. 6

7. Research Vision Committee Taskforces – Key Research Domains • Basic Neuroscience • Chairs: William Carlezon, PhD & Joseph Coyle, MD • Clinical Research: Clinical Trials, Comparative Effectiveness & • Practice-based Evidence Research • Chairs: Shelly Greenfield, MD, MPH & Mary Zanarini, EdD • Neuroimaging • Chairs: Scott Lukas, PhD & Diego Pizzagalli, PhD • Research Considerations for Divisional Roll-out • Chairs: Dost Ongur, MD, PhD & Roger Weiss MD 7

8. Research Vision Committee Charge to Taskforces • Build taskforce with members from within and beyond McLean • Assess domain and evaluate strengths, weaknesses, opportunities and threats • Develop recommendations for action 8

9. Research Vision Committee Timeline • Research Vision Committee (first convened fall 2009 ) • Taskforce Work (Spring/Summer 2010) • Taskforce Reports (Fall 2010) • Prospective Research Priorities – presentation to McLean Board Strategic Implementation Oversight Committee (Spring 2011) 9

10. Research Vision Committee Highlights of Findings & Actions • Basic Neuroscience • Appointed chief of Basic Neuroscience (Joe Coyle) • Identified promising areas: neuroplasticity & drug discovery • Focusing on dynamic space assignment to optimize use of resources • Developing plan for expanding and enhancing wet lab space • Addressing needs for increased rodent housing 10

11. Research Vision Committee Highlights of Findings & Actions • Clinical Research • - Established Clinical Research Center Planning Committee • - Chairs: Jim Hudson & Roger Weiss • - Charge: Assess feasibility, evaluate benefits/risks & develop business plan • * Clinical Research Center (services / facility) • * Clinical Research Infrastructure (e.g., research pharmacy) • Neuroimaging • - Chairs: Scott Lukas & Diego Pizzagalli • - Charge: Plan upgrade of McLean Imaging Center equipment • (e.g., replace 1.5T with 3T magnet) 11

12. Research Vision Committee Highlights of Findings & Actions • Key Recruitments by Division • Basic Neuroscience – established mid-career scientist • - Search identified candidates • - Recruitment ongoing • Chief, Division of Depression, Anxiety & Stress • - Search approved • - Launch anticipated ~December 2011 • Anticipated future searches TBD • - Child & Adolescent Psychiatry Research • - Chief Scientific Officer (~2013) 12

13. Research Impact Institutional Citations Total # articles in ISI Average citations/year Average citations/article % publications in “high impact” journals Weighted average of journal impact for all publications Patents Filed Issued Licensed Research Activity Active Research Funds Submitted Applications Awarded Applications Success Rate Career Development Awards Collaborations Sponsors Research Personnel Research Financials Research Vision CommitteeResearch Metrics 13

14. McLean Hospital Scientific Advisory Board • Charge: Meet annually to review McLean portfolio & advise the President and Board of Trustees • SAB Membership • - Chair, Steve Hyman, MD (Harvard) • - Eric Nestler, MD, PhD (Mt. Sinai) • - Daniel Pine, MD (NIMH Intramural) • - Barbara Rothbaum, PhD (Emory) • - Stephan Heckers, MD (Vanderbilt) • 1st meeting: December 18-19, 2011 • - Focus “Building Centers of Excellence & Innovation” 14

15. McLean Hospital Research Vision Questions & Discussion 15

16. Research Administration Process Improvement (“The Project Plan”)

17. McLean Hospital Research Administration – Project Management • Research Administration Project Management • McLean Steering Committee • Responsibilities – meet every other week (or more if necessary) to: • Assign tasks and initiatives • Monitor plan implementation / progress • Identify obstacles and potential problems; develop plans to appropriately respond • Ensure appropriate resources and prioritization • Provide updates to S. Rauch and P. Markell • Members • Peter Paskevich, Chair (Sr. VP for Research Administration) • Raquel Espinosa (Associate Director, Research Administration) • David Lagasse (CFO) • Catharyn Gildesgame (Director, Strategic Implementation) • Administrative Support • Kim Roselando (Administrative Manager)

18. Project Plan Objectives • Clarify and differentiate roles and responsibilities of McLean PIs, PHS Research Management (RM), McL Research Administration (McL RA) and other key supporting offices • Evaluate re-assignment of roles to PHS RM to take advantage of centralized expertise and economies of scale • Ensure PI’s have appropriate level of support inside/outside their departments

19. Transferring Roles & Responsibilities Re-assignment of roles to PHS Research Management to take advantage of centralized expertise and economies of scale Transfer of Functions PCRO (Partners Clinical Research Office) Industry-sponsored clinical research Tasks: Drafting and negotiating agreements. Projected Volume: 10-15 studies/year RVL (Research Ventures & Licensing) Industry-sponsored pre-clinical research Tasks: Reviewing and negotiating agreements. Projected Volume: 5 - 10/year RVL (Research Ventures & Licensing) Tasks: Intellectual Property Protection, Technology Transfer, MTAs, CDAs, invoicing, tracking and distributing milestone and royalty payments. Projected Volume: 10 new disclosures /year G&C (Grants & Contracts) Tasks: Complex Subcontracts . Projected Volume 10 /year

20. Why this is important and how it will benefit you • Increased efficiency by leveraging PHS Research Management centralized expertise and economies of scale • Improved customer service and efficiency by consolidating functions in specialized offices • Increased accountability through clarification of roles and responsibilities, reporting relationships • Increased support for PIs provided by knowledgeable, effective and efficient key contacts per activity • Competitive budget negotiations with industry sponsors • Licensing and Marketing of inventions

21. Research Metrics

22. Research Metrics

23. Research Expenses FY02 – FY 10 Actuals, FY11 Projected ($000)

24. McLean Hospital IRB Update Research Town Meeting September 28, 2011

25. McLean Hospital • IRB Update • AAHRPP Accreditation • Electronic IRB (eIRB) • IRB Staff Changes

26. draft 9-20-2011

29. Email Migration to Partners Exchange Server

30. Email Migration to Partners Email Timeline • Targeted for early calendar year 2012 • Dependency on PHS readiness of new platform • Timeline assessed weekly with Exchange Team • Provide a 4 week buffer for "transition"

31. Benefits of Migrating to Partners Email • Continue with @mclean.harvard.edu • also receive mail via partners.org, mclean.org • Ability to set any as primary send/receive • Access to the Partners Global Address book • all users across PHS in exchange, auto lookup • Shared Calendar functionality • Integrated Calendar, email, notes, tasks, etc • Email access outside the hospital via robust website • Integration with smart phones (blackberry, iPhone/iPad) • Ability to delegate to administrative managers • Out of office messages to both internal and external recipients • 24x7x365 support

32. What Researchers Have To Do • On the "Transition" day • Configure your email clients to send/receive new email through your partners accounts • Begin transfer of mail out of your existing McLean Email account. Completed before McLean Email server is shutdown (Exact Date TBD) • During transition period you will not loose access to email • Step-by-Step documentation has been developed and posted to the RIS site • McLean RIS/ERIS is on site and ready to assist as needed to configure clients, folders, etc

33. Managing your Mailbox Size • Empty trash regularly • Use http://transfer.partners.org to send large attachments • Archive mail to local folders • Sort Inbox by size and relocate the larger emails

34. Mail Box Storage • Depending upon current usage, 100 or 300 MB to start and you can request up to 1 GB • The request process is currently under development • Larger mailboxes are not free • Low cost associated with it which will be absorbed by McLean IS • Working on a price structure

35. McLean Hospital Q&A / Open Forum

36. Presentation of the Anne M. Cataldo Excellence in Mentoring Award