M ultiscale modelling to predict the risk of osteoporotic bone fractures
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M ultiscale modelling to predict the risk of osteoporotic bone fractures. VPHOP Integrated project. Osteoporosis is a killer. OP fractures kill as many women as breast cancer 30 to 50% of all women and 15 to 30% of all men will face an osteoporotic fracture in their lifetime

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M ultiscale modelling to predict the risk of osteoporotic bone fractures

Multiscale modelling to predict the risk of osteoporotic bone fractures

VPHOP Integrated project


Osteoporosis is a killer
Osteoporosis is a killer

  • OP fractures kill as many women as breast cancer

  • 30 to 50% of all women and 15 to 30% of all men will face an osteoporotic fracture in their lifetime

  • 4,000,000 fractures every year cost Europe €30,000,000,000

  • Forecast to double by 2050

  • 250,000 elders will die of related complications within 12 months, all others will remain impaired


The vphop consortium
The VPHOP Consortium

  • 21 partners

  • 7 industrial partners

  • 5 clinical centres

  • Research leaders in: Biomechanics, biomaterials, computer sciences, biomedical informatics, mechanobiology, CAS, technology assessment, medical imaging & instrument.


Eos tm dual energy system
EOSTM Dual Energy system

  • Scanning area: 5-175 cm (sitting - upright)

  • Sim. bi-planar acquisition, 20 s, head-to-toe

  • Low dose (÷ 10 vs. film/screen)

  • 3D reconstruction of ext. geometry

  • Bi-planar DXA


Actibelt
Actibelt®

  • 3D accelerometer integrated in belt buckle

  • Objective measurement of neuromuscular condition during ambulatory visit

  • Monitoring long term activity (5 days)


Clinical workflow

Organ-level

Model

Personalised risk

of fracture

Clinical workflow

Constitutive Equation

Loading spectrum

Tissue-level

Model

Disease & pharma

(pre-computed)

Effect of augmentation

Body-level

Model

Bone Remodelling

Model

Augmentation

Model


Vphop pr t curve predicted
VPHOP PR(t) curve [predicted]


Disclaimer
Disclaimer

  • VPHOP is a project co-funded by the European Commission Seventh FRAMEWORK PROGRAMME

  • The research reported upon in this presentation has either directly or indirectly been supported by the European Commission, Directorate General Information Society and Media, Brussels.

  • The results, analyses and conclusions derived there from reflect solely the views of its authors and of the presenter.

  • The European Community is not liable for any use that may be made of the information contained therein.