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Immunoglobulin Structure II

Immunoglobulin Structure II. Jr. Hons. Immunology B.Sc. D. I. Stott. Immunoglobulin Domain. IgG Domain Structure: Fab & Fc. 3-D Structure of IgG: whole molecule. 3-D Ribbon Model of Mouse IgG 2a. 3-D Model of IgG1. 3-D Model of IgA. 3-D Model of IgM.

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Immunoglobulin Structure II

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  1. Immunoglobulin Structure II Jr. Hons. Immunology B.Sc. D. I. Stott

  2. Immunoglobulin Domain

  3. IgG Domain Structure: Fab & Fc

  4. 3-D Structure of IgG: whole molecule

  5. 3-D Ribbon Model of Mouse IgG2a

  6. 3-D Model of IgG1

  7. 3-D Model of IgA

  8. 3-D Model of IgM

  9. Electron Micrograph Pictures of IgM Antibodies v. Salmonella Flagella From Stott & Williamson (1982), Comprehensive Biochem. 19B (II) 189-329 and A. Feinstein

  10. Dynamic Changes in IgM Conformation on Binding Antigen (Flagellum)

  11. Shapes of Antigen-binding Sites • Pocket: Hapten (ferrocene) • Groove: HIV peptide • Shallow surface : HEL • Protrusion: HIV gp120

  12. Anti-HIV CD4R SIV HIV envelope spike: gp120/gp41 trimer From Burton et al. (2005), PNAS 102, 14,943 - 48 Anti-gp120 Fab

  13. Lock & Key Theory v. Induced Fit • Lock & Key Theory: Ag fits in Ag B.S. as key in lock • Induced Fit Theory: Ag induces structural change in Ag B.S.  improved fit

  14. Anti-Hen Egg Lysozyme (HEL) Fab + HELLight ChainHeavy ChainHELContact ResiduesAll 6 CDRs contact HELChange in conformation of V domains in Ab/Ag complex

  15. Anti-influenza Neuraminidase • Ab inhibits enzyme activity • Both Ag & Ag B.S. change conformation

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