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Cell-Mediated Cytotoxicity. Cytotoxic T-Lymphocytes Natural Killer Cells Antibody-Dependent, Cell-mediated Cytotoxicity Delayed-type Hypersensitivity. Folder Title: CellKill. Updated: November, 25, 2004. KillTitl.

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Cell-Mediated Cytotoxicity

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cell mediated cytotoxicity
Cell-Mediated Cytotoxicity

Cytotoxic T-Lymphocytes

Natural Killer Cells

Antibody-Dependent, Cell-mediated Cytotoxicity

Delayed-type Hypersensitivity

Folder Title: CellKill

Updated: November, 25, 2004


Cell-Mediated Immunity (CMI):Passive transfer from donor to recipient of cells alone, transfers the immune response function

Response to:

Neoplastic (cancer) Cells

Infected or Altered Cells

Intra-cellular Pathogens


Allo-grafts and other transplants


cell mediated immunity cmi types of cytotoxic cells
Cell-Mediated Immunity (CMI):Types of Cytotoxic Cells

Antigen-Specific T-Cells (Have TCR):

Tc : Cytotoxic T-Cells

TDTH : Delayed-Type Hypersensitivity Cells

("Type IV Hypersensitivity")

Non-Antigen-Specific Cells:


NK Cells

Granulocytes: Neutrophils, Eosinophils, Basophils and

Tissue Mast Cells


ctl binding to target cell

Cytotoxic T-Cell

Binding to

Target Cell

(figure 16-6,

Kuby, 3rd Edition)

CTL binding to Target Cell

TC = Target Cell for

Cytolytic T-Cell

Smaller Cell = CTL


t cell killing by induction of apoptosis figure 16 8 kuby 3rd edition
T-Cell Killing by Induction of Apoptosis(figure 16-8, Kuby, 3rd Edition)

Signals Activation

of Apoptosis

ICE = Interleukin 1

Converting Enzyme


natural killer cell targets and restriction to altered self figure 16 11 kuby 3rd edition
Natural Killer Cell Targets and Restriction to Altered-Self(Figure 16-11, Kuby, 3rd Edition)

No Killing

(Recognized Self;

MHC Class I)

Target Cell Killed

(Did not recognize self;

low MHC Class I