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CELL-MEDIATED IMMUNITY

CELL-MEDIATED IMMUNITY. Antigen presentation Formation of viral proteins by macrophage Formation of antigen-MHC complex. T H cell activation Binding of T H cell to antigen-MHC complex Release of cytokines from macrophage Activation of T H cell to release cytokines.

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CELL-MEDIATED IMMUNITY

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  1. CELL-MEDIATED IMMUNITY • Antigen presentation • Formation of viral proteins by macrophage • Formation of antigen-MHC complex • TH cell activation • Binding of TH cell to antigen-MHC complex • Release of cytokines from macrophage • Activation of TH cell to release cytokines • TC cell activation • Activation of virgin and memory TC cells by cytokines • Promotion of mitosis and differentiation of TC cells • Cellular destruction • Binding of effector TC cell to infected body cell • Induction of cell lysis by release of perforins.

  2. HUMORAL IMMUNITY • Antigen presentation • Formation of viral proteins by macrophage • Formation of antigen-MHC complex • TH cell activation • Binding of TH cell to antigen-MHC complex • Release of cytokines from macrophage • Activation of TH cell to release cytokines • Bcell activation • Activation of virgin and memory B cells by cytokines • Promotion of mitosis and differentiation of B cells • Antibodies production • Release of circulating antibodies into the bloodstream from the plasma cells

  3. ROLE OF CYTOKINES IN ACQUIRED IMMUNITY TNF-b & IFN-g Interleukin 2 Interleukin 1 TNF-b Tumor Necrosis Factor b IFN-g Interferon g

  4. STRUCTURE OF IMMUNOGLOBULIN Glycoprotein molecules produced by plasma cells in response to an antigen Light Chain VL CL VH CH1 CHO Hinge CH2 CH3 Heavy Chain Constant Region Variable Region CHO Domains

  5. STRUCTURES & FUNCTIONS OF IMMUNOGLOBULINS Papain Pepsin Fc Peptides Fab Fc F(ab’) 2 Antigenic binding Effector functions Antigenicbinding & No effector functions

  6. IMMUNOGLOBULIN DIVERSITY

  7. IMMUNOGLOBULINS IN ACTION Opsonization

  8. IMMUNOGLOBULINS IN ACTION Exotoxin Neutralization

  9. IMMUNOGLOBULINS IN ACTION Viral Neutralization

  10. IMMUNOGLOBULINS IN ACTION Complement fixation

  11. IMMUNOGLOBULINS IN ACTION Cytotoxicity

  12. IMMUNOGLOBULINS IN ACTION Agglutination

  13. IMMUNOGLOBULINS IN ACTION

  14. PRIMARY AND SECONDARY IMMUNE RESPONSES

  15. ACTIVE VERSUS PASSIVE IMMUNITY Acquired Immunity Naturally Acquired ArtificiallyAcquired

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