1 / 27

Career Development Grants

Daniel Kreisel MD PhD Washington University in St. Louis. Career Development Grants. Obtain a position on the faculty of a progressive department Develop your research program Secure extramural funding Maintain clinical skills.

vanida
Download Presentation

Career Development Grants

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Daniel Kreisel MD PhD Washington University in St. Louis Career Development Grants

  2. Obtain a position on the faculty of a progressive department Develop your research program Secure extramural funding Maintain clinical skills “The most important time in the career of a young surgical scientist is the first 5 years after completion of surgical training.” S.A. Wells, ASA Presid. Address 1996

  3. “The development of the young surgical scientist is determined primarily by personal qualities (Investigator) and environment.” S.A. Wells, ASA Presid. Address 1996

  4. Career Development Grants • Transition to an independent career as an investigator • Protect time to pursue research • Time lag for CT surgeons between “postdoctoral fellowship” as general surgery resident and first faculty appointment • Enhance “credibility” when applying for independent extramural funding

  5. Career Development Grants • K08 – Mentored Clinical Scientist Research Career Development Award • Laboratory-based research • K23 – Mentored Patient-Oriented Research Career Development Award • Clinically oriented research • K99/R00 – Pathway to Independence Award • 2 years mentored – 3 years independent

  6. K23 • Research conducted with human subjects or material of human origin in which the investigator interacts directly with human subjects • Mechanistic studies of human disease • Evaluation of therapies • Clinical trials • New technology

  7. Eligibility • Principal investigator with a clinical degree (MD, DVM, DDS, DO, PharmD…) • Faculty position must include clinical duties • Follows completion of clinical specialty training • Applicants must have secured faculty position by the time award is made • Applicants are generally within the first 1-3 years of “tenure-track” faculty appointment

  8. Personal Experience • 2002: PhD in Immunology as Surgery Resident • 9/2005: Submitted K08 application while CT Surgery Fellow • 2/2006: Joined faculty at Wash U • 4/2006: 5-year K08 with TSFRE matching funds started • 9/2009: R01 grant

  9. Support • Up to $75,000 salary support / year + fringe benefits • Up to $25,000 support / year for research • Some additional funds from TSFRE (up to $150,000 total funding over five-year award from NHLBI or NCI)

  10. Support • Adequate start-up package • Personnel • Supplies • Animal work is expensive • Access to surgical residents • Funding (i.e. training grants)

  11. Requirements • Dedicated Scientific Mentor • Research Career Development Plan • Appropriate Research Plan for Training • Appropriate Time Commitment • (50-75% Effort for Duration of 3-5 Years)

  12. Caveats • Loss of clinical productivity • Financial penalty for K awardees in Surgery Departments where pay is incentivized based on RVU’s • Economic pressures for societies that have provided matching funds

  13. Critique Criteria • Candidate • Career Development Plan • Research Plan • Mentors / Co-Mentors • Environment

  14. Candidate • Commitment to pursuing research career • Previous research experience • Previous publications • Potential to develop into independent investigator

  15. Career Development • Likelihood that career development plan will contribute to the achievement of SCIENTIFIC INDEPENDENCE

  16. Career Development • Scholarly course work • Address potential deficiencies before embarking on independent career • Consider formal degree (e.g. MPH) • Be specific about time commitment • Seminars, Conferences • Interactions with other scientists

  17. Human Subjects • “Candidates must participate in courses such as data management, epidemiology, study design, hypothesis development, drug development as well as legal and ethical issues associated with research on human subjects.”

  18. Career Development • How are clinical duties and research endeavors integrated? • How many days of clinic, how many days in the OR, call schedule, coverage, transplantation responsibilities? • Commitment from institution and department leadership • Other K awardees in recent past? Their track record?

  19. Research Plan • Significance • Clinical relevance • Innovation • Conceptual • Technical • Approach / Experimental Design • Predicted outcomes • Alternatives • Pitfalls • Statistical considerations

  20. Human Subjects • Tabulate number of human subjects expected • Women, children, minorities • Data safety plan • Monitoring plan • Ensures safety of participants and integrity of data (i.e. reporting of adverse events) • Investigator submits safety data to IRB annually • Data and safety monitoring board

  21. Mentor/Mentors • History of research productivity • Stature in field • Adequate funds to support mentee’s project • NIH funding • Previous experience in fostering independent careers • Table with specifics

  22. Mentor/Mentors • Usually not the clinical supervisor • Should be a basic scientist (K08) with qualifications in area of proposed research • Specifics about mentoring plan • Frequency of meetings • Milestones

  23. Mentor – Advisory Committee • Co-Mentors (Clinical chief if he /she has history of independent research) or advisory committee can be helpful • Frequent meetings to evaluate progress

  24. Environment • Resources • Institutional commitment to development of career as independent investigator • Balance research activity – clinical duties

  25. Grant Submission • Simultaneous submission to NIH and TSFRE • Review by NIH study section • Secondary review by NIH council to determine funding • TSFRE provides funds to applicants, who receive funding from NIH

  26. Funding Record K grants /TSFRE • 2012: K08 NCI • 2011: K23 NHLBI • 2010: K08 NHLBI x 2 • 2009: K08 NHLBI x 2, K23 NCI • 2008: K08 NCI x 2, K23 NCI • 2006: K08 NHLBI x 3 • 2005: K08 NHLBI, K23 NCI

  27. Conclusions • K grants are an important mechanism to achieve status as independent investigator in cardiothoracic surgery • Key factors • Personal commitment • Suitable mentors • Institutional / departmental / divisional support

More Related