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Career Development Grants

Career Development Grants

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Career Development Grants

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  1. Career Development Grants American College of Epidemiology Annual Meeting September 17, 2007 Faith Davis, PhD, University of Illinois at Chicago Jennifer Peel, PhD, Colorado State University

  2. Career Development Awards • This presentation will focus on NIH awards • Many other organizations have similar awards, e.g., • American Cancer Society • American Lung Association • American Heart Association • Centers for Disease Control and Prevention • And likely many more…

  3. 28th Annual American College of Epidemiology Meeting Marriott Harbor Beach Resort Ft. Lauderdale, FL. September 17, 2007 NIH Support For Research Training And Career Development in Epidemiology NCI Cancer Training Branch Lester S. Gorelic, Ph.D. Program Director, Clinical/Prevention Sciences gorelicl@mail.nih.gov

  4. National Cancer Institute Cancer Training Branch (CTB)* • Interim Branch Chief: • J. Carl Oberholtzer oberholtzerc@mail.nih.gov • Program Directors: • Lester Gorelic gorelicl@mail.nih.gov • Sonia Jakowlew jakowles@mail.nih.gov • Shannon Lemrow lemrows@mail.nih.gov • Nancy Lohrey lohreyn@mail.nih.gov • Dorkina Myrick myrickd@mail.nih.gov *:cancer.gov/researchandfunding/training

  5. Learning Objectives • Where to find information • What is available • What is provided • How to choose the support that best meets your needs

  6. Organization Of Presentation • Overview • Institutional programs • Individual awards • Administrative supplements • Putting it all together

  7. Conventions • NIH funding mechanisms used in place of program names • Blue: NCI-specific programs • Red:Clinicians only • Caveat: Will discuss only those programs that conceivably can be used for training and CD in epidemiology. To be sure, contact the component NIH institute

  8. Overview

  9. Where To Find Information • Office of Extramural Research: Funding: http://grants.nih.gov/training/index.htm • Extramural (Outside of NIH): • Ruth L. Kirchstein National Research Service Awards (NRSA) • Career Development (K) Awards • Relevant linkshttp://grants.nih.gov/training/extramural.htm http://grants.nih.gov/training/nrsa.htm http://grants.nih.gov/training/careerdevelopmentawards.htm

  10. Where To Find Information, cont’d • Office of Extramural Research: Funding: • Extramural, cont’d: • Selected programs for special populations: Research supplements to promote diversity in health-related research: http://grants.nih.gov/grants/guide/pa-files/PA-05-015.html • Intramural (within NIH) http://www.training.nih.gov/ • Individual NIH institute websites

  11. Where To Find Information, cont’d • NIH Wide Initiatives: Roadmap for Biomedical Research • Provides a framework of the priorities the NIH must address in order to optimize its entire research portfolio • Focus: • New pathways to discovery • Research teams of the future • Re-engineering the clinical research enterprise • Relevant link: http://nihroadmap.nih.gov/

  12. Where To Find Information, cont’d • NIH Wide Initiatives: Roadmap for Biomedical Research, cont’d • Multidisciplinary Clinical Research Career Development programs • Training an Interdisciplinary Workforce • Relevant links http://nihroadmap.nih.gov/ http://nihroadmap.nih.gov/clinicalresearch/clinicaltraining/futureleaders.asphttp://grants.nih.gov/training/T_Table.htm

  13. Institutional Programs

  14. Institutional Programs • Generallyfor individuals with a limited number of publications (if consistent with program selection criteria) or unable to obtain a strong institutional commitment to career development (pre, postdoc) • Individuals apply to an ongoing program for a “slot” • Prepares an individual to apply for an individual research career (K) award; if appointed as a predoc, a postdoc fellowship (F32); or an R-grant • Provides a training experience in biomedical research

  15. Institutional Programs, cont’d • NRSA T32 & T90 • Training experience in biomedical research (T32) or interdisciplinary research (T90) • NCI supports ca. 170 T32 programs, 11 focus specifically on epidemiology • K12 programs • “Physician scientist” career development programs • Roadmap initiative • NCIR25T programs • NCI supports 40 R25T programs • 4 of the R25T’s specifically focus on epidemiology

  16. Institutional ProgramsBasic provisions & requirements

  17. T32 & T90 Programs • PI is an established investigator • Trainees (predoc, postdoc) must be US citizens or permanent residents (not for an NIH T90) • Requires full-time (40 hr/week) commitment

  18. T32 & T90 Programs, cont’d • Up to 5 years of predoc, 3 years postdoc support is possible • Legislated stipend levels • No support for research • Institutional allowance for training expenses

  19. K12Programs • Two types: Clinicians only. Clinicians & postdoctoral Ph.D.’s • Provides salary and research support • Requires ≥ 75% effort commitment • May have core didactic requirements • May require multiple mentors • May have a specific research focus § • Must contact sponsoring NIH institute for specifics

  20. The NCI R25TProgram • Curriculum-based predoc/postdoc/Jr. faculty program with required didactic and “laboratory” requirements • Requires multiple mentors for each appointee • Does not require 75% percent or full-time effort commitment • Support for curriculum development, implementation, evaluation, PI salary • Salary and research support for appointees

  21. Individual Awards

  22. Individual Awards • Fellowships (F’s) and Career Awards (K’s) • Mentored ((K01, K08), K07, K23, F31, F32) • “Transitioning” or “Cross” (K99/R00, K22’s) award • Unmentored K’s (New (K22’s) & Established)

  23. Individual (K&F) Awards • Not R grants • K & F’ s are for individuals who can demonstrate the need for additional training/career development before they are fully independent • R grants are for independent investigators • K & F’s focus on training or career development • R-grant focus is on research

  24. Individual (K&F) Awards • Not R grants, cont’d • Multiple interconnected elements • PI, sponsor (mentor), mentor’s statement §, training/career development plan (K’s), research plan, institutional commitment, environment • R grants: PI, research, environment • K’s generally reviewed at the institute level (not F’s) • Unsolicited R-grants (and F’s) are reviewed at CSR §

  25. Individual Awards • Support a research career development experience (K’s) or research training experience (F’s) • Prepare an F32 awardee to apply for a K-award/R-grant or a K-awardee to apply for an R-grant

  26. Fellowships • F’s can be used to support up to 3 years of mentored postdoc (F32) or up to 5 years (F31) of mentored predoc research training • Generally applicable to any area of biomedical research • Purpose of the F-program could be to increase the diversity of the biomedical research work force (NCI F31)

  27. K-Awards • Can be used to support up to 5 years of mentored research career development leading to independent investigator status (K01, NCI K07; K08, K23) • Can be used to provide protected (unmentored) time to “new” investigators to initiate their first independent research program (K22)

  28. K-Awards, cont’d • Can be used to support a mentored research experience followed by a transition to and support during an independent position (K99/R00, K22) • Individual K’s generally applicable to a specific aspect of biomedical research (viz., basic science, patient-oriented research) and research career stage

  29. Individual AwardsBasicProvisions & Requirements

  30. Mentored Individual Awards • Fellowships: F31,F32 • Need a sponsor • Need publications (not an F31) • Do not need institutional commitment • K-Awards:K01,K07, K08, K23 • Postdoctoral (fellows) to junior faculty • Need a mentor • Need publications • Need strong institutional commitment

  31. Mentored Individual Awards, General Provisions • Three (F32) to five year (F31, K’s) non-renewable • US Citizen or permanent resident • Require full-time (F31, F32) or at least 75% effort commitments (K’s) • Mentors • Provide stipends (F31, F32) or salaries (K’s) • Provide research support (K’s)

  32. “Cross” Or “Transitioning”Awards • K22’s • Pathway to Independence Award (K99/R00)* http://grants.nih.gov/grants/new_investigators/pathway_independence.htm; http://grants.nih.gov/grants/guide/pa-files/PA-07-297.html • Facilitate a “seamless” transition of individuals from postdoc to independent investigator • Supports up to 1-2 years of mentored postdoctoral training (K99) followed by • Support of up to 3 years for protected time as an independent investigator to initiate first independent research program (R00) *NCI limits use to basic science research in human cancer

  33. Individual Awards: Independent • NCI Transition Career Development Awards (K22) • Provides protected time (up to 3 years) to newly independent* investigators to initiate their first independent research program • NCI limits award to POR, CPCBPS;and basic science PhD’s (working in human cancer systems) in Federal intramural settings • Do not need a sponsoring institution at the time of application *: Moving from a postdoc position including a mentored K-grant to a first independent research position or ≤ 2 yrs in 1st independent position

  34. Administrative Supplements To Enhance Diversity In Biomedical Research • NIH: • Supplements to research project grants (RPG’s) • All stages in career development • Supplements to T32 grants • NCI: CURE program • NCI: • Supplements to R25T programs (CURE program) • Candidates contact the grant/program PI

  35. Putting it all together

  36. Continuum Of Opportunities Newly Independent Mentored Predoc Post/Fellow Jr.Faculty T32 T90/R00 R25T T32 T90/R00 R25T K12 R25T K12 K22 K01 K07 K08 K23 F32 K07 F31

  37. Continuum Of Opportunities Newly Independent Mentored Predoc Post/Fellow Jr.Faculty T32 T90/R00 R25T T32 T90/R00 R25T K12 R25T K12 K22 K01 K07 K08 K23 F32 K07 F31 K22 K22

  38. Continuum Of Opportunities Newly Independent Mentored Predoc Post/Fellow Jr.Faculty T32 T90/R00 R25T T32 T90/R00 K22 K99 R00 F31

  39. Resources For Success Rates T32’s : 1996-2006: http://grants.nih.gov/grants/award/training/train9606.htm K-awards: up to 2005: http://grant.nih.gov/training/data/rcpsucc.xls

  40. 28th Annual American College of Epidemiology Meeting Marriott Harbor Beach Resort Ft. Lauderdale, FL. September 17, 2007 NIH Support For Research Training And Career Development in Epidemiology NCI Cancer Training Branch Lester S. Gorelic, Ph.D. Program Director, Clinical/Prevention Sciences gorelicl@mail.nih.gov

  41. Training and Career Development Awards for Pre-Docs, Post-Docs and Junior Faculty Lynda Lisabeth University of Michigan Departments of Epidemiology and Neurology

  42. Background • PhD in Epidemiology (2003) • Joined neurology faculty in 2003 • K23 • National Institute for Neurologic Disorders and Stroke (NINDS) • September 2005 – May 2010 • Stroke population • In-person interviews • Blood draws

  43. Feedback from Reviewers • Piggy backed on R01 • Mechanisms in place • Clear mentoring plan (frequency of meetings, information on past trainees, etc.) • Multiple mentors • Commitment to other projects • ≥75% effort • Overlap with ongoing studies – uniqueness

  44. Feedback from Reviewers • Travel – on-site research, scientific meetings • Career development plan – mix theoretical, hands on experience and coursework • Support from Department Chair • Research space, start-up funds

  45. Lessons Learned • High scientific interest, unique study population, need for well trained researchers • Contact Project Officer • Prior to submitting grant • Copy grant to PO at time of submission • Review successful K grant applications • Preliminary data • Feasibility of proposed research

  46. Lessons Learned • Detailed career development plan • Discuss Reviewer comments with PO (conference call), include mentor on call • Publication track record • Number of publications • Topic of K award

  47. Training and Career Development Awards for Pre-Docs, Post-Docs and Junior Faculty Charlotte Joslin University of Illinois at Chicago Department Ophthalmology and Visual Science Division of Epidemiology, School of Public Health

  48. K23 Award, National Eye Institute (NEI) September 2004 – August 2009 Clinical research background Mostly a clinician (70% time in clinic) NEI-sponsored prospective cohort study: institution Co-Investigator FDA clinical trials: institution PI and Co-Investigator Industry sponsored research K23 Award PhD in epidemiology Determining corneal and intraocular lens power in post-LASIK eyes needing cataract surgery and intraocular lens implant Background

  49. Feedback from Reviewers • Candidate and Career Development Plan • Demonstrate productivity and research potential: papers, collaborations, recent activity • Career goals – bespecific! • Demonstrate aptitude and interest in goals • Provide specific details about plans: coursework, seminars, meetings, travel, etc.

  50. Feedback from Reviewers • Mentors and Institutional Commitment • Highly qualified mentors with federal funding • Diverse mentor expertise • Meet training and research goals of project • Institutional commitment releasing time for research • Research Plan • “Appropriate to primary goal . . . a mentored research experience which she can accomplish within the proposed time period and that builds on her current expertise while allowing her to expand her skills in new areas.”