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Analysis of lytic proteins pinholin and Rz/Rz1

Analysis of lytic proteins pinholin and Rz/Rz1. Sue Parks and Lawangin Khan. Lytic Cassette. S. R. Rz. Rz1. Comparative analysis of Trans-Membrane domain Motifs in pinholin proteins. Two Domains in the Pinholin Protein. Figure 1D: Phage S21 reading frame.

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Analysis of lytic proteins pinholin and Rz/Rz1

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  1. Analysis of lytic proteins pinholin and Rz/Rz1 Sue Parks and Lawangin Khan

  2. Lytic Cassette S R Rz Rz1

  3. Comparative analysis of Trans-Membrane domain Motifs in pinholin proteins

  4. Two Domains in the Pinholin Protein Figure 1D: Phage S21 reading frame Pang et al.(2010) Mutational Analysis of S21 pinholin. Molecular Biology, 76(1): 66-77.

  5. Traditional Holin Model TM2 TM1 TM3

  6. Text TMD1 TMD2

  7. Motifs MXXM TMD1 TMD2

  8. Comparative analysis of lysis protein, Rz1 cleavage sites • Lawangin Khan

  9. Localization? Why Cleave? Cleave site

  10. Cleavage site conserved? Determining cleavage site • Determined by LipoP, (www.cbs.dtu.dk/services/LipoP/)

  11. Comparative Analysis

  12. Relative Consensus and Position • Krupovic’s lipobox consensus: L(A/S)(G/A)C

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