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Bone Tissue. A. Physiology: functions of bone B. Anatomy: structure of bone C. Histology of bone D. Bone homeostasis 1. Remodeling 2. Bone's role in calcium homeostasis. Physiology: Functions of Bone. 1. support 2. protection 3. movement

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Bone Tissue


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bone tissue
Bone Tissue
  • A. Physiology: functions of bone
  • B. Anatomy: structure of bone
  • C. Histology of bone
  • D. Bone homeostasis

1. Remodeling

2. Bone's role in calcium homeostasis

physiology functions of bone
Physiology: Functions of Bone
  • 1. support
  • 2. protection
  • 3. movement
  • 4. mineral homeostasis
  • 5. blood cell production (hematopoiesis)
  • 6. energy storage
shapes of bones
Shapes of Bones
  • 1. long
  • 2. short
  • 3. flat
  • 4. irregular
types of bone
Types of Bone
  • 1. compact (dense)
  • 2. spongy (cancellous)
long bone anatomy
Long Bone Anatomy
  • 1. diaphysis
  • 2. epiphysis
  • 3. metaphysis
  • 4. epiphyseal plate

(Read bone dvp. pg. 220-227)

  • 5. articular cartilage
  • 6. articular surfaces
  • 7. periosteum

a. fibrous

b. osteogenic

  • 8. medullary cavity
  • 9. endosteum
bone cell types
Bone Cell Types
  • 1. osteoprogenitor cells
  • 2. osteoblasts -- (osteogenesis)
  • 3. osteocytes– (strain sensors)
  • 4. osteoclasts -- (bone resorption/osteolysis)
bone matrix
Bone Matrix
  • 1. ground substance (25%)
  • 2. collagen (25%)
  • 3. mineral salts (50%)

-- tricalcium phosphate (hydroxyapatite)

-- ossification

bone histology
Bone Histology
  • 1. Haversian system
  • (osteon)
  • 2. Haversian canal
  • 3. lacuna
  • 4. lamella
  • 5. canaliculus
bone and calcium homeostasis
Bone and Calcium Homeostasis
  • 1. remodeling
  • 2. serves to:
  • a. resist mechanical stress
  • b. remove worn bone
  • c. store calcium

(1) parathyroid hormone and vitamin D

(2) calcitonin

slide10

Less kidney reabsorption

(more calcium excretion)

(osteogenesis)

> 10.5 mg/dL

(osteolysis)

(Intestinal absorption too)

< 9.5mg/dL

slide11

CALCITONIN and BLOOD CALCIUM REGULATION

negative feedback

CONTROLLED CONDITION

Normocalcemia

(blood calcium = 9.5-10.5mg%)

A stress or stimulus causes an increase in blood calcium

RETURN TO HOMEOSTASIS

Increased bone formation results in increased calcium deposition in bone –

Return to normocalcemia

RECEPTOR

Parafollicular cells of thyroid gland recognize hypercalcemia

(blood calcium >10.5 mg%

EFFECTORS

Reduced osteoclast activity

Increased osteoblast activity

CONTROL CENTER

Parafollicular cells secrete calcitonin

slide12

PTH and BLOOD CALCIUM REGULATION

negative feedback

CONTROLLED CONDITION

Normocalcemia

(blood calcium = 9.5-10.5mg%)

A stress or stimulus causes a decrease in blood calcium

RETURN TO HOMEOSTASIS

Increased bone breakdown results in increased calcium release to blood –

Return to normocalcemia

RECEPTOR

EFFECTORS

Chief cells of parathythyroid glands recognize hypocalcemia

(blood calcium <9.5 mg%

Increased osteoclast activity

Decreased osteoblast activity

Increased urine phosphate output

Decreased urine calcium output

CONTROL CENTER

Chief cells secrete PTH

end