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Ce KIN-29 436 EN RRH T LCAS Rn SIK1 470 TG RRH T LAEV Mm SIK2 497 QQ RRH T LSEV

A. Ce KIN-29 250 LNPG KRY T IQ Rn SIK1 261 VDPA KRI T IA Mm SIK2 254 LDPS KRL S IA Hs SIK3 242 LDPN KRL S ME. Ce KIN-29 436 EN RRH T LCAS Rn SIK1 470 TG RRH T LAEV Mm SIK2 497 QQ RRH T LSEV. Ce KIN-29 508 PVPKSE- RRA S AGETLLP Rn SIK1 567 PVSFQEG RRA S DTSLTQG

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Ce KIN-29 436 EN RRH T LCAS Rn SIK1 470 TG RRH T LAEV Mm SIK2 497 QQ RRH T LSEV

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  1. A Ce KIN-29 250 LNPGKRYTIQ Rn SIK1 261 VDPAKRITIA Mm SIK2 254 LDPSKRLSIA Hs SIK3 242 LDPNKRLSME Ce KIN-29 436 ENRRHTLCAS Rn SIK1 470 TGRRHTLAEV Mm SIK2 497 QQRRHTLSEV Ce KIN-29 508 PVPKSE-RRASAGETLLP Rn SIK1 567 PVSFQEGRRASDTSLTQG Mm SIK2 577 PVSFREGRRASDTSLTQG Hs SIK3 493 NGMGPLGRRASDGGANIQ B Ce HDA-4 452 KCEKVTAKKASLEQLQLVHS Hs HDAC4 697 KCECIRGRKATLEELQTVHS Hs HDAC5 726 KCERIRGRKATLDEIQTVHS van der Linden et al_Supplemental Figure 2

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